CAJ | 학술논문

目的了解异质性万古霉素中介耐药金黄色葡萄球菌(h-VISA)在本院的感染情况,探讨不同最低抑菌浓度(MIC)的原代菌株间h-VISA检出率的差异.方法采用琼脂稀释法检测甲氧西林耐药的金黄色匍萄球菌(MRSA)对万古霉素的MIC值,用菌群分析法筛选h-VISA,计算h-VISA的检出率.结果 45株MRSA中共检出h-VISA 7株,检出率为15.6%,原代菌对万古霉素MIC值越高,h-VISA检出率越高.结论本院存在h-VISA感染情况,应引起一定重视,系统地监测h-VISA的流行情况,对指导临床正确使用万古霉素,防止VISA和VRSA的出现有重要意义.
목적 료해이질성만고매소중개내약금황색포도구균(h-VISA)재본원적감염정황,탐토불동최저억균농도(MIC)적원대균주간h-VISA검출솔적차이.방법 채용경지희석법검측갑양서림내약적금황색포도구균(MRSA)대만고매소적MIC치,용균군분석법사선h-VISA,계산h-VISA적검출솔.결과 45주MRSA중공검출h-VISA 7주,검출솔위15.6%,원대균대만고매소MIC치월고,h-VISA검출솔월고.결론 본원존재h-VISA감염정황,응인기일정중시,계통지감측h-VISA적류행정황,대지도림상정학사용만고매소,방지VISA화VRSA적출현유중요의의.
Objective To investigate the prevalence of heterogeneous vancomycin-intermediate staphy-lococcus aureu (h-VISA) infection situation in our hospital, and to discuss the relationship between separation rate'and MICs of parent strains. Methods The MICs of the oxacillin-resistance staphylococcus aureu (MRSA) were tested by agar dilution method and population analysis profiles to screen h-VISAs, computed the separation rate and analyzed relationships between these strains and MICs of their parent strains. Results 7 strains were detected as h-VISAs,with a separation rate of 15.6%. More h-VISAs can be detected in strains with higher MICs to vancomyein. Conclusion A certain separation rate of h-VISA had been detected in our hospital, which could be worth noticing. Monitoring the spreading of h-VISA in the hospital would assist using vancomycin cor-rectly and prevent the appearances of VISA or VRSA.