中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2010年
9期
622-625
,共4页
李友海%汪凯%陈先文%刘平%席春华%程怀东
李友海%汪凱%陳先文%劉平%席春華%程懷東
리우해%왕개%진선문%류평%석춘화%정부동
帕金森病%时间知觉%认知
帕金森病%時間知覺%認知
파금삼병%시간지각%인지
Parkinson disease%Time perception%Cognition
目的 探讨帕金森病(Pakinson's disease,PD)患者的时间感知障碍.方法 采用时距复制的检查方法,对32例原发性PD患者和32名健康对照者进行时间感知能力测试.结果 在3s的时间复制任务中,PD患者组在延迟1s[(2.15±0.34)s]和延迟5 s[(2.08±0.37)s]的情况下时间复制能力明显下降,表现为低估时间,与对照组[分别为(2.78±0.31)s和(2.74±0.32)s]相比差异均有统计学意义(t=-7.459、-7.533,均P＜0.01);在5 s的时间复制任务中,PD患者组在延迟1 s[(3.11±0.52)s]和延迟5 s[(2.96±0.54)s]的情况下时间复制能力较对照组[分别为(3.99±0.39)s和(4.05±0.40)s]亦有明显下降,表现为低估时间,差异均有统计学意义(t=-7.609、-9.120,均P＜0.01);但在600ms的时间复制中,PD患者组在延迟1 s[(0.90±0.18)s]和延迟5 s[(0.91±0.17)s]的情况下时间复制能力与对照组[分别为(0.91±0.18)s和(0.89±0.16)s]相比差异无统计学意义(t=0.347、-0.519,P=0.730、0.606).结论 PD患者存在时间感知障碍,主要表现为对秒以上长时距的低估,而对毫秒范围内的短时距感知无损伤.
目的 探討帕金森病(Pakinson's disease,PD)患者的時間感知障礙.方法 採用時距複製的檢查方法,對32例原髮性PD患者和32名健康對照者進行時間感知能力測試.結果 在3s的時間複製任務中,PD患者組在延遲1s[(2.15±0.34)s]和延遲5 s[(2.08±0.37)s]的情況下時間複製能力明顯下降,錶現為低估時間,與對照組[分彆為(2.78±0.31)s和(2.74±0.32)s]相比差異均有統計學意義(t=-7.459、-7.533,均P＜0.01);在5 s的時間複製任務中,PD患者組在延遲1 s[(3.11±0.52)s]和延遲5 s[(2.96±0.54)s]的情況下時間複製能力較對照組[分彆為(3.99±0.39)s和(4.05±0.40)s]亦有明顯下降,錶現為低估時間,差異均有統計學意義(t=-7.609、-9.120,均P＜0.01);但在600ms的時間複製中,PD患者組在延遲1 s[(0.90±0.18)s]和延遲5 s[(0.91±0.17)s]的情況下時間複製能力與對照組[分彆為(0.91±0.18)s和(0.89±0.16)s]相比差異無統計學意義(t=0.347、-0.519,P=0.730、0.606).結論 PD患者存在時間感知障礙,主要錶現為對秒以上長時距的低估,而對毫秒範圍內的短時距感知無損傷.
목적 탐토파금삼병(Pakinson's disease,PD)환자적시간감지장애.방법 채용시거복제적검사방법,대32례원발성PD환자화32명건강대조자진행시간감지능력측시.결과 재3s적시간복제임무중,PD환자조재연지1s[(2.15±0.34)s]화연지5 s[(2.08±0.37)s]적정황하시간복제능력명현하강,표현위저고시간,여대조조[분별위(2.78±0.31)s화(2.74±0.32)s]상비차이균유통계학의의(t=-7.459、-7.533,균P＜0.01);재5 s적시간복제임무중,PD환자조재연지1 s[(3.11±0.52)s]화연지5 s[(2.96±0.54)s]적정황하시간복제능력교대조조[분별위(3.99±0.39)s화(4.05±0.40)s]역유명현하강,표현위저고시간,차이균유통계학의의(t=-7.609、-9.120,균P＜0.01);단재600ms적시간복제중,PD환자조재연지1 s[(0.90±0.18)s]화연지5 s[(0.91±0.17)s]적정황하시간복제능력여대조조[분별위(0.91±0.18)s화(0.89±0.16)s]상비차이무통계학의의(t=0.347、-0.519,P=0.730、0.606).결론 PD환자존재시간감지장애,주요표현위대초이상장시거적저고,이대호초범위내적단시거감지무손상.
Objective To explore the impairment of time perception in patients with Parkinson's disease (PD).Method Thirty-two individuals with idiopathic PD were compared with 32 matched healthy controls using a time reproduction task.Result Compared with healthy controls for the 3-second duration reproduction task, PD patients in the setting of a delay by 1 s ( (2.78 ±0.31 ) s and (2.15 ±0.34) s,respectively) and a delay by 5 s ( (2.74 ±0.32) s and (2.08 ±0.37) s, respectively) showed impairment in time perception with a significant under-estimation of the duration ( t = - 7.459, - 7.533, both P ＜0.01 ).When compared with healthy controls for the 5-second duration reproduction task, PD patients in the setting of a delay by 1 s ( (3.99 ±0.39) s and (3.11 ±0.52) s) and 5 s ( (4.05 ±0.40) s and (2.96 ±0.54) s) also showed impairment in time perception with a significant under-estimation of the duration (t =-7.609 and - 9.120, both P ＜ 0.01 ).When compared with healthy controls for the 600-millisecond duration reproduction task, PD patients in the setting of delay by 1 s ((0.91 ±0.18) s and (0.90 ±0.18) s, respectively) and by 5 s ( (0.89 ± 0.16) s and (0.91 ± 0.17 ) s, respectively) did not have impaired time perception, and the difference was not significant ( t = 0.347, P = 0.730; t = - 0.519, P =0.606, respectively).Conclusion Our data indicates that time perception is impaired in PD patients.Impaired time perception is mainly an under-estimation of the time interval in seconds rather than milliseconds.
