CAJ | 학술논문

目的对64层螺旋CT血管造影(CTA)诊断椎动脉狭窄的文献进行荟萃分析,评价64层螺旋CTA对椎动脉狭窄的诊断价值.方法以64层螺旋CT、血管造影、椎动脉狭窄等为检索词,检索Cochrane图书馆、PubMed、EBSCO、中国生物医学文献数据库、清华同方全文数据库等的中文和英文文献.对符合纳人标准的文献进行质量评估、异质性检验.汇总敏感性和特异性,通过汇总受试者工作特征曲线(SROC)和曲线下面积(AUC)以及诊断优势比(DROC)评价64层螺旋CT对椎动脉狭窄的诊断价值.结果共纳入4篇中文文献,1篇A级,3篇B级.异质性检验发现纳入研究不存在异质性,采用固定效应模型计算.其中对椎动脉狭窄≥50%的汇总敏感性、特异性、DROC和SROC AUC分别为0.98(0.94～1.00)、0.93(0.89～0.96),526.33和0 9899;对椎动脉狭窄≥70%分别为0.98(0 91～1.00)、0.97(0.94～0.99),838.40和0.9932.结论 64层螺旋CTA诊断椎动脉狭窄有较高的敏感性和特异性.但还需要高质量的前瞻性研究以更准确地评价其临床价值.
목적 대64층라선CT혈관조영(CTA)진단추동맥협착적문헌진행회췌분석,평개64층라선CTA대추동맥협착적진단개치.방법 이64층라선CT、혈관조영、추동맥협착등위검색사,검색Cochrane도서관、PubMed、EBSCO、중국생물의학문헌수거고、청화동방전문수거고등적중문화영문문헌.대부합납인표준적문헌진행질량평고、이질성검험.회총민감성화특이성,통과회총수시자공작특정곡선(SROC)화곡선하면적(AUC)이급진단우세비(DROC)평개64층라선CT대추동맥협착적진단개치.결과 공납입4편중문문헌,1편A급,3편B급.이질성검험발현납입연구불존재이질성,채용고정효응모형계산.기중대추동맥협착≥50%적회총민감성、특이성、DROC화SROC AUC분별위0.98(0.94～1.00)、0.93(0.89～0.96),526.33화0 9899;대추동맥협착≥70%분별위0.98(0 91～1.00)、0.97(0.94～0.99),838.40화0.9932.결론 64층라선CTA진단추동맥협착유교고적민감성화특이성.단환수요고질량적전첨성연구이경준학지평개기림상개치.
Objective To evaluate the diagnostic value of 64-slice spiral computed tomographic angiography (CTA) in vertebral artery stenosis through a meta-analysis of the relevant data. Methods A database search of Cochrane Library, PubMed, EBSCO, CBM-disc and CNKI was performed to identify the relevant English and Chinese language articles with such keywords as 64-slice computer tomography,angiography and vertebral artery stenosis. Quality evaluation, heterogeneity test and sensitivity and specificity to the qualified original data were conducted. Summary receiver operating characteristic (SROC)curve, the area under curve (AUC) and diagnostic odds ratio (DROC) were also calculated. Results A total of 4 studies were eligible for meta-analysis. Among them, 1 was graded as A and 3 were graded as B.No heterogeneity was found based upon a fixed effect model. For vertebral artery stenosis ≥50% , the pooled weighted sensitivity, specificity, DROC and SROC AUC was 0.98 (0.94-1.00) , 0.93 (0.89-0.96) ,526.33 and 0.9899 respectively; while for vertebral artery stenosis ≥50% , the parameters were 0.98(0.91-1.00), 0.97 (0.94-0.99), 838.40 and 0.9932 respectively. Conclusions 64-slice spiral CTA has such a high level of accuracy, sensitivity and specificity in the non-invasive diagnosis of vertebral artery stenosis.