中国普外基础与临床杂志
中國普外基礎與臨床雜誌
중국보외기출여림상잡지
CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY
2001年
3期
159-161，163
,共4页
胆囊结石%糖代谢%脂代谢
膽囊結石%糖代謝%脂代謝
담낭결석%당대사%지대사
目的探讨糖脂代谢在胆囊结石形成中的作用。方法收集1998年1～4月 25例胆囊结石患者和25例自愿者，并应用性别和年龄进行个体配对（1∶1），测量所有研究对象的体重指数（BMI）和腰臀比（W/H），并采空腹静脉血测定血糖、糖化血红蛋白（HbA1C）、胰岛素、C肽以及血脂全套指标，采血后研究对象立即口服75g葡萄糖，2小时后再测定血糖、胰岛素、C肽。结果结石组与对照组的BMI和W/H无明显统计学差异。两组空腹血糖、HbA1C及2小时血糖差异无统计学意义（P>0.05、P>0.2、P>0.1）。结石组中糖代谢异常10例，占40%（7例糖尿病，3例糖耐量减低），对照组糖代谢异常4例（1例糖尿病，3例糖耐量减低），差异有显著性意义（P<0.05）。结石组空腹及2小时胰岛素平均浓度明显高于对照组（P<0.02, P<0.05），结石组空腹C肽亦高于对照组（P<0.05）。结石组中高胰岛素血症14例，对照组2例，差异有显著性意义（P<0.01）。两组血脂各项指标（TG、TC、HDL-C、LDL-C、VLDL-C）无统计学差异。结论糖尿病和胰岛素水平升高在胆囊结石形成中可能有重要作用。
目的探討糖脂代謝在膽囊結石形成中的作用。方法收集1998年1～4月 25例膽囊結石患者和25例自願者，併應用性彆和年齡進行箇體配對（1∶1），測量所有研究對象的體重指數（BMI）和腰臀比（W/H），併採空腹靜脈血測定血糖、糖化血紅蛋白（HbA1C）、胰島素、C肽以及血脂全套指標，採血後研究對象立即口服75g葡萄糖，2小時後再測定血糖、胰島素、C肽。結果結石組與對照組的BMI和W/H無明顯統計學差異。兩組空腹血糖、HbA1C及2小時血糖差異無統計學意義（P>0.05、P>0.2、P>0.1）。結石組中糖代謝異常10例，佔40%（7例糖尿病，3例糖耐量減低），對照組糖代謝異常4例（1例糖尿病，3例糖耐量減低），差異有顯著性意義（P<0.05）。結石組空腹及2小時胰島素平均濃度明顯高于對照組（P<0.02, P<0.05），結石組空腹C肽亦高于對照組（P<0.05）。結石組中高胰島素血癥14例，對照組2例，差異有顯著性意義（P<0.01）。兩組血脂各項指標（TG、TC、HDL-C、LDL-C、VLDL-C）無統計學差異。結論糖尿病和胰島素水平升高在膽囊結石形成中可能有重要作用。
목적탐토당지대사재담낭결석형성중적작용。방법수집1998년1～4월 25례담낭결석환자화25례자원자，병응용성별화년령진행개체배대（1∶1），측량소유연구대상적체중지수（BMI）화요둔비（W/H），병채공복정맥혈측정혈당、당화혈홍단백（HbA1C）、이도소、C태이급혈지전투지표，채혈후연구대상립즉구복75g포도당，2소시후재측정혈당、이도소、C태。결과결석조여대조조적BMI화W/H무명현통계학차이。량조공복혈당、HbA1C급2소시혈당차이무통계학의의（P>0.05、P>0.2、P>0.1）。결석조중당대사이상10례，점40%（7례당뇨병，3례당내량감저），대조조당대사이상4례（1례당뇨병，3례당내량감저），차이유현저성의의（P<0.05）。결석조공복급2소시이도소평균농도명현고우대조조（P<0.02, P<0.05），결석조공복C태역고우대조조（P<0.05）。결석조중고이도소혈증14례，대조조2례，차이유현저성의의（P<0.01）。량조혈지각항지표（TG、TC、HDL-C、LDL-C、VLDL-C）무통계학차이。결론당뇨병화이도소수평승고재담낭결석형성중가능유중요작용。
Objective To study the effects of glucose and lipid metabolism on gallstone formation. Methods Twenty five patients with gallstones and 25 normal volunteer controls were studied from January to April in 1998. The patients were well matched the control with sex and age (1∶1). In the study, Body Mass Index (BMI) and Waist-to-Hip circumference ratio (W/H) were measured. Blood glucose, glucosylated hemoglobin (HbA1C), insulin, C peptide and all parameters of lipids were detected at fasting state. The glucose,insulin, C peptide were detected again at 2-hour after taking 75g glucose orally. Results The result showed there was no difference on BMI and W/H between the patients and controls. HbA1C、mean fasting and 2-hour glucose concentration were not in significantly different between the two groups (P>0.05, P>0.2, P>0.1 respectively). There were 10 patients with abnormal glucose metabolism (7 with NIDDM, 3 with IGT), but only 4 controls were abnoumal (one with NIDDM, three with IGT). The difference was significant (P<0.05). Furthermore, the mean fasting and 2-hour insulin concentration of gallstone group was higher than that of the control (P<0.02, P<0.05). And the gallstone group had a higher fasting C peptide concentration than control (P<0.05). There was no statistical difference on the parameters of plasma lipid between the tow groups. Conclusion The study suggests that diabetes mellious and hyperinsulinemia acted as an important role on gallstone formation.
