CAJ | 학술논문

目的为了解奥克托今的危害程度及其发病情况，制订我国车间空气中奥克托今最高容许浓度(MAC)和时间加权平均容许浓度(TWA)。方法进行了奥克托今的毒理学研究、职业流行病学调查研究，并与其同系物黑索今进行了对比。结果奥克托今对大鼠属实际无毒性物质，对小鼠有轻微毒性，奥克托今属中等蓄积性物质，无皮肤刺激作用，无致癌、致畸、致突变作用。动物实验及流行病学观察，其中毒症状主要表现为神经系统异常改变，重度者还出现肾小管变化或明显的肝脏中毒改变。奥克托今毒性远小于黑索今。结论提出我国车间空气中奥克托今最高容许浓度建议值为4 m g/m3，时间加权平均容许浓度为2 mg/m3。
목적위료해오극탁금적위해정도급기발병정황，제정아국차간공기중오극탁금최고용허농도(MAC)화시간가권평균용허농도(TWA)。방법진행료오극탁금적독이학연구、직업류행병학조사연구，병여기동계물흑색금진행료대비。결과오극탁금대대서속실제무독성물질，대소서유경미독성，오극탁금속중등축적성물질，무피부자격작용，무치암、치기、치돌변작용。동물실험급류행병학관찰，기중독증상주요표현위신경계통이상개변，중도자환출현신소관변화혹명현적간장중독개변。오극탁금독성원소우흑색금。결론제출아국차간공기중오극탁금최고용허농도건의치위4 m g/m3，시간가권평균용허농도위2 mg/m3。
Objective The aim of this study is to inve stigate the occupational health risk level and the adverse effects of octogen,and to establish the maximum allowable concentration(MAC)and the time weighted average concentration(TWA)of octogen in the air of workplaces in this country.Methods Toxicological study and epidemiological investigation of octogen were conducted.The comparison between octogen and hexogen was made.Results　Octogen may b e considered practically non-toxic in rats and slightly toxic in mice.It may also be consi-dere d a medium cumulative chemical.It has no irritant action to the skin.Its not carcinogenic,teratogenic or mutagenic.By animal experiment and epidemiological observation,toxic symptom of octogen was mainly the nervous system abnormality.The tubular kidney changes and significant toxic liver changes were observed in severe toxic animal experiment.The toxicity of octogen seemed lower than that of hexogen.Conclusions　It is proposed that MAC for octogen in the air of workplaces in this country may be set as 4 mg/m3,and its TWA 2 mg/m3。