中南大学学报（医学版）
中南大學學報（醫學版）
중남대학학보（의학판）
JOURNAL OF CENTRAL SOUTH UNIVERSITY (MEDICAL SCIENCES)
2010年
3期
203-208
,共6页
郭皖北%车志宏%徐爱民%周智广
郭皖北%車誌宏%徐愛民%週智廣
곽환북%차지굉%서애민%주지엄
代谢综合征%血管生成素样蛋白3%脂联素
代謝綜閤徵%血管生成素樣蛋白3%脂聯素
대사종합정%혈관생성소양단백3%지련소
metabolic syndrome%angiopoietin-like protein 3%adiponectin
目的:探讨代谢综合征患者血清脂联素和血管生成素样蛋白3(angiopoietin-like protein 3,Angptl3)水平的变化及其意义. 方法:对111例代谢综合征患者和152例健康对照,采用单克隆抗体双夹心酶联免疫法测定血清Angptl3及脂联素水平,分析血清脂联素、Angptl3与脂代谢和胰岛素抵抗的关系.结果:代谢综合征组血清脂联素水平为4.22(1.01～23.29) μg/mL,低于对照组5.41(0.97～22.27) μg/mL(P＜0.05),Angptl3在2组间差异无统计学意义.Angptl3与脂联素正相关(P＜0.001);脂联素与高密度脂蛋白胆固醇(HDL-C)正相关(P＜0.001),与体质量指数(BMI)、腰围(WC)、腰臀比(WHR)、甘油三酯(TG)、空腹血糖(FPG)、空腹胰岛素(FINS)、稳态模型评估的胰岛素抵抗指数(homeostatic model assessment method-insulin resistance,HOMA-IR)均呈负相关(P＜0.001).多元回归分析显示,脂联素是Angptl3的独立决定因素(b′=0.256,P＜0.001).脂联素与TG,HOMA-IR呈负相关(分别b′ =-0.234, b′=-0.145, P＜0.001).结论:代谢综合征患者血清脂联素水平降低,可能与Angptl3水平降低有关.
目的:探討代謝綜閤徵患者血清脂聯素和血管生成素樣蛋白3(angiopoietin-like protein 3,Angptl3)水平的變化及其意義. 方法:對111例代謝綜閤徵患者和152例健康對照,採用單剋隆抗體雙夾心酶聯免疫法測定血清Angptl3及脂聯素水平,分析血清脂聯素、Angptl3與脂代謝和胰島素牴抗的關繫.結果:代謝綜閤徵組血清脂聯素水平為4.22(1.01～23.29) μg/mL,低于對照組5.41(0.97～22.27) μg/mL(P＜0.05),Angptl3在2組間差異無統計學意義.Angptl3與脂聯素正相關(P＜0.001);脂聯素與高密度脂蛋白膽固醇(HDL-C)正相關(P＜0.001),與體質量指數(BMI)、腰圍(WC)、腰臀比(WHR)、甘油三酯(TG)、空腹血糖(FPG)、空腹胰島素(FINS)、穩態模型評估的胰島素牴抗指數(homeostatic model assessment method-insulin resistance,HOMA-IR)均呈負相關(P＜0.001).多元迴歸分析顯示,脂聯素是Angptl3的獨立決定因素(b′=0.256,P＜0.001).脂聯素與TG,HOMA-IR呈負相關(分彆b′ =-0.234, b′=-0.145, P＜0.001).結論:代謝綜閤徵患者血清脂聯素水平降低,可能與Angptl3水平降低有關.
목적:탐토대사종합정환자혈청지련소화혈관생성소양단백3(angiopoietin-like protein 3,Angptl3)수평적변화급기의의. 방법:대111례대사종합정환자화152례건강대조,채용단극륭항체쌍협심매련면역법측정혈청Angptl3급지련소수평,분석혈청지련소、Angptl3여지대사화이도소저항적관계.결과:대사종합정조혈청지련소수평위4.22(1.01～23.29) μg/mL,저우대조조5.41(0.97～22.27) μg/mL(P＜0.05),Angptl3재2조간차이무통계학의의.Angptl3여지련소정상관(P＜0.001);지련소여고밀도지단백담고순(HDL-C)정상관(P＜0.001),여체질량지수(BMI)、요위(WC)、요둔비(WHR)、감유삼지(TG)、공복혈당(FPG)、공복이도소(FINS)、은태모형평고적이도소저항지수(homeostatic model assessment method-insulin resistance,HOMA-IR)균정부상관(P＜0.001).다원회귀분석현시,지련소시Angptl3적독립결정인소(b′=0.256,P＜0.001).지련소여TG,HOMA-IR정부상관(분별b′ =-0.234, b′=-0.145, P＜0.001).결론:대사종합정환자혈청지련소수평강저,가능여Angptl3수평강저유관.
Objective To investigate the changes of serum angiopoietin-like protein 3 (Angptl3) and adiponectin levels in patients with metabolic syndrome (MS) in order to understand their association with the MS. Methods Serum Angptl3 and adiponectin levels were measured by sandwich ELISA in a group of 111 patients with MS and 152 normal controls. Results Serum adiponectin was lower in the MS patients than in the control subjects [4.22(1.01-23.29) μg/mL vs. 5.41(0.97-22.27) μg/mL, P＜0.05]. With regard to serum Angptl3, there was no significant difference between the 2 groups(P＞0.05). Serum adiponectin was correlated to Angptl3 and high density lipoprotein-cholesterol (HDL-C)(P＜0.001) and negatively correlated to body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), triglyceride (TG), fasting plasma glucose (FBG), fasting insulin (FINS) and homeostatic model assessment method-insulin resistance (HOMA-IR) (P＜0.001). Serum Angptl3 was positively correlated with adiponectin (P＜0.001). Serum adiponectin was found to be independently positive determinant for Angptl3 concentrations (b′=0.256, P＜0.001). Adiponectin was inversely correlated with TG and HOMA-IR (b′=-0.234, -0.145, P＜0.001). Conclusion Adiponectin is decreased in MS patients and may be correlated to Angptl3.
