CAJ | 학술논문

目的观察血糖控制未达标2型糖尿病患者血糖波动与认知功能的关系.方法采用问卷调查的方法评定认知功能,比较不同血糖波动组间认知功能的差异,并对认知功能与问卷当日的血糖波动情况等进行相关性分析.结果 (1)日7次血糖的均数、标准差、血糖波动及总血糖在不同HbA1c组间有统计学差异(P＜0.01);(2)不同血糖波动组间认知功能有统计学差异(P＜0.05),但性别、年龄、受教育年限等方面却无统计学差异(P＞0.05);(3)认知功能与检查当日7次血糖的平均值、最高血糖水平、最低血糖水平、血糖波动幅度及总血糖水平等均呈负相关.结论血糖控制未达标2型糖尿病患者认知功能与血糖波动密切相关.减少血糖波动对认知功能的保护有着重要的意义.
목적 관찰혈당공제미체표2형당뇨병환자혈당파동여인지공능적관계.방법 채용문권조사적방법평정인지공능,비교불동혈당파동조간인지공능적차이,병대인지공능여문권당일적혈당파동정황등진행상관성분석.결과 (1)일7차혈당적균수、표준차、혈당파동급총혈당재불동HbA1c조간유통계학차이(P＜0.01);(2)불동혈당파동조간인지공능유통계학차이(P＜0.05),단성별、년령、수교육년한등방면각무통계학차이(P＞0.05);(3)인지공능여검사당일7차혈당적평균치、최고혈당수평、최저혈당수평、혈당파동폭도급총혈당수평등균정부상관.결론 혈당공제미체표2형당뇨병환자인지공능여혈당파동밀절상관.감소혈당파동대인지공능적보호유착중요적의의.
Objective To study the relationship between the glucose fluctuation and the cognitive function in patients with badcontrolled type 2 diabetes mellitus (T2DM). MethodsQuestionnaires were used to study cognitive function and to analyze the correlation of cognitive function and the levels of glucose fluctuation. Results （1）The mean, range and sum of the 7pointdaily capillary glucose showed differences with statistical significance between the HbA1c≥8.5% and ＜8.5% groups(P＜0.01). （2）There were significant differences between the groups of glucose fluctuation ≥7.1mmol/L and ＜7.1mmol/L,in the the delayed and clued body regions memory and the second auditory immediate memory(P＜0.05). Sex, age, educational level, duration of diabetes, the level of systolic pressure and diastolic pressure, and HbA1c had no difference between the two groups(P＞0.05). （3）Cognitive function showed a negative correlation with mean blood glucose(MBG, r=-0.185),the highest and lowest glucose levels (r=-0.275, r=-0.236), the range of glucose fluctuation (r=-0.287)，the sum of the 7pointdaily capillary glucose(r=-0.234). Conclusions The glucose fluctuation has obvious correlation with cognitive function in badcontrolled T2DM patients. Controlling glucose effectively and reducing the glucose fluctuation will be beneficial for improving cognitive function.