CAJ | 학술논문

Toll样受体11(Toll-like receptor 11)是近年来发现的Toll样受体家族的成员之一,在人类因开放读框中有数个终止密码子而不表达蛋白,且不能识别泌尿系统致病性大肠杆菌,这可能是人对泌尿系统疾病存在易感性的原因之一.该受体可在小鼠体内完整表达,与病原体相关配体结合通过相应的信号通路促进rh1型细胞免疫应答,从而发挥其抗感染作用.深入研究TLR11的结构和功能有助于理解宿主抗某些寄生虫病的保护性机制,由此制定相应的预防和治疗对策.
Toll양수체11(Toll-like receptor 11)시근년래발현적Toll양수체가족적성원지일,재인류인개방독광중유수개종지밀마자이불표체단백,차불능식별비뇨계통치병성대장간균,저가능시인대비뇨계통질병존재역감성적원인지일.해수체가재소서체내완정표체,여병원체상관배체결합통과상응적신호통로촉진rh1형세포면역응답,종이발휘기항감염작용.심입연구TLR11적결구화공능유조우리해숙주항모사기생충병적보호성궤제,유차제정상응적예방화치료대책.
Toll-like receptor 11 ( TLR11 ) was found as a member of Toll-like receptor family in recent years. It does not express full-length protein due to the existence of several stop codons in the open reading frame (ORF) of human beings and it can not recognize uropathogenic Escherichia coli. Therefore,it might be one of the reasons of susceptibility of the urinary systemic diseases in humans. Mice can express the full-length protein of TLR11 that recognizes pathogen-associated molecular patterns (PAMPs) to promote Th1 type cellmediated immune response via initiating corresponding signal pathways, and therefore resist some infections.Further studies on the structure and functions of TLR11 will contribute to better understanding of the protective mechanism against some parasitic infections in the host,thus to help making some measures for prevention and therapy.