国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
4期
245-248
,共4页
郭艳玲%刘洋%时广利%操敏%贾红艳%荣长利%尹颜军%宋长兴
郭豔玲%劉洋%時廣利%操敏%賈紅豔%榮長利%尹顏軍%宋長興
곽염령%류양%시엄리%조민%가홍염%영장리%윤안군%송장흥
白介素1%受体%基因多态性%肺癌
白介素1%受體%基因多態性%肺癌
백개소1%수체%기인다태성%폐암
Interleukin-1%Receptor%Gene polymorphism%Lung cancer
目的 对肺癌患者和健康人的白介素1受体拮抗剂基因(interleukin-1 receptor antagonist gene,IL-1RN)多态性进行研究,探讨IL-1RN与肺癌易感性的关系.方法 采用聚合酶链式反应技术对148例肺癌患者和150名健康对照者的IL-1RN基因多态性进行分析.结果 Ⅱ类等位基因(IL-1RN*2)显著降低肺癌发生风险(OR=0.46,95%CI:0.23～0.93).与转移患者和Ⅱ～Ⅳ期患者比较后发现IL-1RN*2与风险性显著降低有关(OR=0.37,95%CI:0.14～0.98;OR=0.38,95%CI:0.16～0.87).结论 IL-1RN*2可以降低肺癌发生风险,可能与肺癌的转移和进展有关.
目的 對肺癌患者和健康人的白介素1受體拮抗劑基因(interleukin-1 receptor antagonist gene,IL-1RN)多態性進行研究,探討IL-1RN與肺癌易感性的關繫.方法 採用聚閤酶鏈式反應技術對148例肺癌患者和150名健康對照者的IL-1RN基因多態性進行分析.結果 Ⅱ類等位基因(IL-1RN*2)顯著降低肺癌髮生風險(OR=0.46,95%CI:0.23～0.93).與轉移患者和Ⅱ～Ⅳ期患者比較後髮現IL-1RN*2與風險性顯著降低有關(OR=0.37,95%CI:0.14～0.98;OR=0.38,95%CI:0.16～0.87).結論 IL-1RN*2可以降低肺癌髮生風險,可能與肺癌的轉移和進展有關.
목적 대폐암환자화건강인적백개소1수체길항제기인(interleukin-1 receptor antagonist gene,IL-1RN)다태성진행연구,탐토IL-1RN여폐암역감성적관계.방법 채용취합매련식반응기술대148례폐암환자화150명건강대조자적IL-1RN기인다태성진행분석.결과 Ⅱ류등위기인(IL-1RN*2)현저강저폐암발생풍험(OR=0.46,95%CI:0.23～0.93).여전이환자화Ⅱ～Ⅳ기환자비교후발현IL-1RN*2여풍험성현저강저유관(OR=0.37,95%CI:0.14～0.98;OR=0.38,95%CI:0.16～0.87).결론 IL-1RN*2가이강저폐암발생풍험,가능여폐암적전이화진전유관.
Objective To investigate the relationship between interleukin-1 receptor antagonist gene (IL-1RN) polymorphism and the susceptibility of lung cancer by studying IL-1RN gene polymorphism of lung cancer patients and healthy people. Methods IL-1RN gene polymorphism in 148 patients with lung cancer and 150 healthy individuals was analyzed by polymerase chain reaction. Results The class Ⅱ allele (IL- 1RN * 2) significantly reduced the risk of lung cancer (OR=0.46,95% CI:0.23-0.93). IL-1RN*2was associated with significantly reduced risk by comparing with transfer patients and Ⅱ -Ⅳ stage patients (OR =0.37,95%CI :0.14-0.98;OR=0.38,95%CI:0.16-0.87).Conclusions IL-1RN*2 canreduce the risk of lung cancer, may be related to metastasis and progression of lung cancer.
