国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2010年
17期
2116-2119
,共4页
心跳骤停%心肺复苏%纳络酮%肾上腺素
心跳驟停%心肺複囌%納絡酮%腎上腺素
심도취정%심폐복소%납락동%신상선소
Cardiac arrest%Cardiac pulmonary cerebral resuscitation%Naloxon%Epinephrine
目的 研究院前心跳骤停患者在心肺脑复苏中应用不同剂量纳络酮的临床疗效.方法 在113例心跳骤停患者中随机分为三组,常规对照组(A组)37例,小剂量纳络酮组(B组)36例,大剂量纳络酮组(C组)40例,各组分别观察自主循环恢复率、自主呼吸恢复率、出院存活率、脑复苏率、自主循环恢复时间及自主呼吸恢复时间.结果 C组(57.50%)自主循环恢复率明显高于A组(24.32%)、B组(27.78%),C组(52.5%)自主呼吸恢复率也明显高于A组(18.91%)、B组(22.22%),且均差异有显著性(P＜0.01);出院存活率、脑复苏率三组比较差异无显著性(P＞0.05): C组(10.5±3.1m)自主循环恢复时间短于A组(19.5±3.7)min、B组(18.8±3.5)min(P＜0.01),C组自主呼吸恢复时间(14.8±3.9)min短于A组(28.6±4.5)min、B组(26.9±3.7)min(P＜0.01).结论 在院前心跳骤停患者中应用大剂量纳络酮可明显提高自主循环恢复率、自主呼吸恢复率,缩短自主循环、自主呼吸恢复时间.
目的 研究院前心跳驟停患者在心肺腦複囌中應用不同劑量納絡酮的臨床療效.方法 在113例心跳驟停患者中隨機分為三組,常規對照組(A組)37例,小劑量納絡酮組(B組)36例,大劑量納絡酮組(C組)40例,各組分彆觀察自主循環恢複率、自主呼吸恢複率、齣院存活率、腦複囌率、自主循環恢複時間及自主呼吸恢複時間.結果 C組(57.50%)自主循環恢複率明顯高于A組(24.32%)、B組(27.78%),C組(52.5%)自主呼吸恢複率也明顯高于A組(18.91%)、B組(22.22%),且均差異有顯著性(P＜0.01);齣院存活率、腦複囌率三組比較差異無顯著性(P＞0.05): C組(10.5±3.1m)自主循環恢複時間短于A組(19.5±3.7)min、B組(18.8±3.5)min(P＜0.01),C組自主呼吸恢複時間(14.8±3.9)min短于A組(28.6±4.5)min、B組(26.9±3.7)min(P＜0.01).結論 在院前心跳驟停患者中應用大劑量納絡酮可明顯提高自主循環恢複率、自主呼吸恢複率,縮短自主循環、自主呼吸恢複時間.
목적 연구원전심도취정환자재심폐뇌복소중응용불동제량납락동적림상료효.방법 재113례심도취정환자중수궤분위삼조,상규대조조(A조)37례,소제량납락동조(B조)36례,대제량납락동조(C조)40례,각조분별관찰자주순배회복솔、자주호흡회복솔、출원존활솔、뇌복소솔、자주순배회복시간급자주호흡회복시간.결과 C조(57.50%)자주순배회복솔명현고우A조(24.32%)、B조(27.78%),C조(52.5%)자주호흡회복솔야명현고우A조(18.91%)、B조(22.22%),차균차이유현저성(P＜0.01);출원존활솔、뇌복소솔삼조비교차이무현저성(P＞0.05): C조(10.5±3.1m)자주순배회복시간단우A조(19.5±3.7)min、B조(18.8±3.5)min(P＜0.01),C조자주호흡회복시간(14.8±3.9)min단우A조(28.6±4.5)min、B조(26.9±3.7)min(P＜0.01).결론 재원전심도취정환자중응용대제량납락동가명현제고자주순배회복솔、자주호흡회복솔,축단자주순배、자주호흡회복시간.
Objective To study the efficacy of naloxon at different doses during cardiac pulmonary cerebral resuscitation (CPCR) for prehospital cardiac arrest patients. Methods 113 patients were randomly assigned to control group (37 patients, group A), low-dose naloxon group (36 patients, group B),or high-dose naloxon group (40 patients, group C). The recovery rates of circulation and respiration, the survival rate, the rate of cerebral resuscitation, and the time to recovery of circulation and respiration were observed. Results The recovery rate of circulation was significantly higher in group C than in groups A and B (57.50% vs. 24.32% vs. 27.78%, P＜ 0.01). The recovery rate of respiration was markedly higher in group C than in groups A and B (52.5% vs. 18.91% vs. 22.22%, P＜ 0.01). The survival rate and the rate of cerebral resuscitation did not differ significantly among all the groups (P＞ 0.05). The time to recovery of circulation was significantly shorter in group C than in groups A and B [(10.5 ± 3. 1)m vs. (19.5 ± 3.7)m vs. (18.8 ± 3.5)m, P＜0.01]. The time to recovery of respiration was shorter in group C than in groups A and B [(14.8 ± 3.9)m vs. (28.6 ± 4.5)m vs. (26.9 ± 3.7)m, P＜0.01). Conclusions High-dose naloxon for prehospital cardiac arrest patients during CPCR can significantly increase the recovery rate of circulation and respiration and shorten the time to recovery of circulation and respiration.
