CAJ | 학술논문

骨髓间充质干细胞(BMSCs)是一种主要存在于骨髓中具有自我更新和多向分化潜能的干细胞.由于其具有体外无限增生、自我更新和能够分化成体内各种细胞的潜能,已经成为组织工程、细胞移植及基因治疗理想的靶细胞.在眼科相关研究中,BMSCs移植的研究主要集中于角膜病及视网膜疾病的治疗,视网膜疾病的治疗方式又可分为玻璃体腔注射和视网膜下移植,两者均有一定的治疗效果,而关于视神经疾病的治疗方面,国内外的研究较少.BMSCs的研究为解决当前眼科疾病治疗提供了新的思路和前景,但研究仍处于动物实验阶段,要进一步进行临床试验还有许多问题需要解决.就BMSCs的研究发展概况及其在眼科的研究进展进行综述.
골수간충질간세포(BMSCs)시일충주요존재우골수중구유자아경신화다향분화잠능적간세포.유우기구유체외무한증생、자아경신화능구분화성체내각충세포적잠능,이경성위조직공정、세포이식급기인치료이상적파세포.재안과상관연구중,BMSCs이식적연구주요집중우각막병급시망막질병적치료,시망막질병적치료방식우가분위파리체강주사화시망막하이식,량자균유일정적치료효과,이관우시신경질병적치료방면,국내외적연구교소.BMSCs적연구위해결당전안과질병치료제공료신적사로화전경,단연구잉처우동물실험계단,요진일보진행림상시험환유허다문제수요해결.취BMSCs적연구발전개황급기재안과적연구진전진행종술.
Bone marrow stem cells (BMSCs) are a type of self-renewing,multipotential stem cell group that mainly locate in bone marrow.Due to their great expansion,seLf-renewing and the potential ability of differentiating into a wide variety of cell types,BMSCs have become ideal target cells of tissue engineering,cell transplantation and gene therapy.The ophthalmology-related BMSCs research is primarily focused on the therapy of the corneal diseases and retinal diseases.The therapy of the retinal diseases include vitreous cavity injection and subretina transplantation.Both of them get some exciting effectiveness.However,less reports of the application of BMSCs in optic nerve diseases are seen up to now.The research about BMSCs provides a new clue for solving the modern ophthalmology diseases.But the research remains still in an animal experiment stage.Many relevant problems need to solve prior to its going into clinical trial.This review sumumarized the development,characteristics and prospect of BMSCs.