CAJ | 학술논문

目的检测血浆8-异前列腺素F2α8-iso-PGF2α及血清C-反应蛋白(CRP)水平在单纯阻塞性睡眠呼吸暂停低通气综合征(OSAHS)及合并高血压患者中的变化,探讨OSAHS的病理生理变化及合并高血压的发病机制.方法单纯OSAHS患者19例,OSAHS合并高血压患者21例,同期健康体检者20例,分别用ELISA法检测3组研究对象血浆8-iso-PGF2α血清CRP的水平并进行比较.结果单纯OSAHS组血浆8-iso-PGF2α(11.08±3.26)μg/L]及血清CRP[(1.75±0.82)mg/L]水平均高于健康对照组[分别为(7.49±2.10)μg/L与(0.52±0.26)mg/L,P均<0.01].OSAHS合并高血压患者血浆8-iso-PGF2α[(14.84±3.43)μg/L]及血清CRP[(3.13±1.06)mg/L]水平均高于单纯OSAHS患者及健康对照组(P均<0.01).结论 OSAHS患者存在炎症及氧化应激水平升高,并参与OSAHS合并高血压的发生发展.
목적 검측혈장8-이전렬선소F2α8-iso-PGF2α급혈청C-반응단백(CRP)수평재단순조새성수면호흡잠정저통기종합정(OSAHS)급합병고혈압환자중적변화,탐토OSAHS적병리생리변화급합병고혈압적발병궤제.방법 단순OSAHS환자19례,OSAHS합병고혈압환자21례,동기건강체검자20례,분별용ELISA법검측3조연구대상혈장8-iso-PGF2α혈청CRP적수평병진행비교.결과 단순OSAHS조혈장8-iso-PGF2α(11.08±3.26)μg/L]급혈청CRP[(1.75±0.82)mg/L]수평균고우건강대조조[분별위(7.49±2.10)μg/L여(0.52±0.26)mg/L,P균<0.01].OSAHS합병고혈압환자혈장8-iso-PGF2α[(14.84±3.43)μg/L]급혈청CRP[(3.13±1.06)mg/L]수평균고우단순OSAHS환자급건강대조조(P균<0.01).결론 OSAHS환자존재염증급양화응격수평승고,병삼여OSAHS합병고혈압적발생발전.
Objective To investigate the plasma 8-iso-prostaglandin F2α(8-iso-PGF2α and the serum C-re-active protein(CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) with and without hypertension(OSAHS + HT),and to explore the changes of pathophysiology in patients with OSAHS and the patho-genesis of OSAHS + HT. Methods All observed subjects were divided into 3 groups: control group (n=20),OS-AHS group(n=19),OSAHS + HT group (n=21). Plasma 8-iso-PGF2αand serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2αand serum CRP levels,were higher in OSAHS patients than those in control subjects [(11.08±3.26)μg/L vs (7.49±2.10)μg/L,P<0.01;(1.75±0.82) mg/L vs (0.52±0.26 ) mg/L,P<0.01],and were higher in OSAHS + HT group than those in control group [14.84±3.43)μG/L vs(11.08±3.26)μg/L,P<0.01 ;(3.13±1.06)mg/L vs(1.75±0.82)mg/L,P<0.01]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased,which are involved in the devel-opment of OSAHS associated hypertension.