CAJ | 학술논문

在调强放疗的常规分割研究中,肿瘤靶区内放射敏感性不同的区域所需要的放疗剂量也应该不尽相同.对于放疗中肿瘤局部或全部达到CR的靶区是否有残留的肿瘤细胞是实施放疗补量的重要前提.这使以CT解剖影像学为基础的放疗靶区研究成为瓶颈.对此,通过PET/CT功能性成像研究实施的、以反映与肿瘤细胞放射敏感性和细胞增殖有关的细胞代谢、乏氧和细胞周期各时相DNA动态变化的生物靶区构建研究,将成为重要的研究领域.
재조강방료적상규분할연구중,종류파구내방사민감성불동적구역소수요적방료제량야응해불진상동.대우방료중종류국부혹전부체도CR적파구시부유잔류적종류세포시실시방료보량적중요전제.저사이CT해부영상학위기출적방료파구연구성위병경.대차,통과PET/CT공능성성상연구실시적、이반영여종류세포방사민감성화세포증식유관적세포대사、핍양화세포주기각시상DNA동태변화적생물파구구건연구,장성위중요적연구영역.
In studies on intensity modulated radiotherapy with conventional fractionation,different radiosensitivity areas require different irradiation doses.In tumor radiotherapy areas CR,boosts in radiotherapy doses should be determined according to whether there are survived tumor cells or not.To those survived cells,CT imaging has become the key tool to delineate the radiotherapy target.Thus,the study on the construction of biological target volume with PET/CT functional imaging,which could reflect either radiosensitivity or cell proliferation-related cell metabolism,anoxia and DNA number of various cell cycle phases,is an important research area.