CAJ | 학술논문

目的探讨胃肠道间质瘤(gastrointestinal stromal tumor,GIST)肝转移的诊断和治疗.方法回顾性分析1993年12月至2007年5月收治的16例GIST肝转移患者的临床资料.结果 14例行根治性切除术,2例行姑息性切除术.3例根治性切除术及2例姑息性切除术患者术后服用伊马替尼治疗.术后随访时间3～161个月,14例根治性切除患者中共8例复发、转移.其中7例肝转移,3例采用肝动脉栓塞治疗,1例服用伊马替尼,2例手术切除,1例未治疗;1例腹壁转移,行手术切除.本组16例患者1、3年生存率分别为92%和74%.结论 GIST肝转移术后复发率高,手术治疗GIST肝转移及术后复发、转移效果较好,联合服用伊马替尼可进一步提高患者生存率.
목적 탐토위장도간질류(gastrointestinal stromal tumor,GIST)간전이적진단화치료.방법 회고성분석1993년12월지2007년5월수치적16례GIST간전이환자적림상자료.결과 14례행근치성절제술,2례행고식성절제술.3례근치성절제술급2례고식성절제술환자술후복용이마체니치료.술후수방시간3～161개월,14례근치성절제환자중공8례복발、전이.기중7례간전이,3례채용간동맥전새치료,1례복용이마체니,2례수술절제,1례미치료;1례복벽전이,행수술절제.본조16례환자1、3년생존솔분별위92%화74%.결론 GIST간전이술후복발솔고,수술치료GIST간전이급술후복발、전이효과교호,연합복용이마체니가진일보제고환자생존솔.
Objective To investigate the diagnosis and treatment of hepatic metastasis from gastrointestinal stromal turnor(GIST).Methods The clinical data of 16 patients with GIST who had been admitted to our hospitalfrom December 1993 to May 2007 were retrospectively analyzed.Results Of all patients,14 underwent radical resection and 2 underwent palliative operation.Two patients with palliative operation and 3 with radical resection were administered with imatinib postoperatively. All patients were followed up for 3-161 months,and GIST metastasis and invasion was observed in 8 of the 14 patients who received radical resection.Of the 7 patients with hepatic metastasis.3 were treated with hepatic artery chemoembolization,1 was administered with imatinib,2 received reoperation and 1 did not receive any treatment. Reoperation was carried out on 1 patient who had abdominal wall metastasis.The 1-and 3-year survival rates of the 16 patients were 92%and 74%,respectively.Conclusions The recurrence rate of GIST after hepatectomy is high.Complete surgical resection is the best curative treatment for hepatic metastasis from GIST and GIST recurrence.The combination of surgical resection and imatinib administration may help to improve the prognosis of patients with hepatic metastasis from GIST.