中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2011年
3期
231-235
,共5页
梁勇%赵明威%潘中婷%侯宪如%任泽钦%黎晓新
樑勇%趙明威%潘中婷%侯憲如%任澤欽%黎曉新
량용%조명위%반중정%후헌여%임택흠%려효신
新生血管性青光眼%抗VEGF治疗%全视网膜光凝
新生血管性青光眼%抗VEGF治療%全視網膜光凝
신생혈관성청광안%항VEGF치료%전시망막광응
Neovascular glaucoma%Anti-VEGF injection%Pan-retinal photocoagulation
目的 建立以完成全视网膜光凝为目标,抗VEGF治疗和抗青光眼手术为核心治疗手段的新生血管性青光眼(neovascular glaucoma,NVG)的综合治疗方法,探讨NVG的治疗策略.方法 设计NVG治疗流程,纳入NVG患者9例10只眼进行综合治疗,治疗方法包括药物降眼压、眼内抗VEGF治疗、单独或联合白内障及玻璃体切割手术的抗青光眼手术以及在此基础上完成全视网膜光凝治疗.随诊6～18(平均9.7)个月,观察患者眼压、视功能及虹膜及房角新生血管状况.结果 本组患者治疗前眼压(42.30±10.25)mmHg,治疗后末次随诊眼压(17.30±4.86)mmHg,统计学分析差异具有统计学意义(P＜0.001).治疗后7只眼视力明显提高.末次随诊时8只眼虹膜及房角新生血管消退.结论 以完成全视网膜光凝为目标,抗VEGF治疗和抗青光眼手术为手段的NVG综合治疗方法能有效控制患者眼压并最大限度保护患者的视功能.
目的 建立以完成全視網膜光凝為目標,抗VEGF治療和抗青光眼手術為覈心治療手段的新生血管性青光眼(neovascular glaucoma,NVG)的綜閤治療方法,探討NVG的治療策略.方法 設計NVG治療流程,納入NVG患者9例10隻眼進行綜閤治療,治療方法包括藥物降眼壓、眼內抗VEGF治療、單獨或聯閤白內障及玻璃體切割手術的抗青光眼手術以及在此基礎上完成全視網膜光凝治療.隨診6～18(平均9.7)箇月,觀察患者眼壓、視功能及虹膜及房角新生血管狀況.結果 本組患者治療前眼壓(42.30±10.25)mmHg,治療後末次隨診眼壓(17.30±4.86)mmHg,統計學分析差異具有統計學意義(P＜0.001).治療後7隻眼視力明顯提高.末次隨診時8隻眼虹膜及房角新生血管消退.結論 以完成全視網膜光凝為目標,抗VEGF治療和抗青光眼手術為手段的NVG綜閤治療方法能有效控製患者眼壓併最大限度保護患者的視功能.
목적 건립이완성전시망막광응위목표,항VEGF치료화항청광안수술위핵심치료수단적신생혈관성청광안(neovascular glaucoma,NVG)적종합치료방법,탐토NVG적치료책략.방법 설계NVG치료류정,납입NVG환자9례10지안진행종합치료,치료방법포괄약물강안압、안내항VEGF치료、단독혹연합백내장급파리체절할수술적항청광안수술이급재차기출상완성전시망막광응치료.수진6～18(평균9.7)개월,관찰환자안압、시공능급홍막급방각신생혈관상황.결과 본조환자치료전안압(42.30±10.25)mmHg,치료후말차수진안압(17.30±4.86)mmHg,통계학분석차이구유통계학의의(P＜0.001).치료후7지안시력명현제고.말차수진시8지안홍막급방각신생혈관소퇴.결론 이완성전시망막광응위목표,항VEGF치료화항청광안수술위수단적NVG종합치료방법능유효공제환자안압병최대한도보호환자적시공능.
Objective To establish the efficacy and safety of comprehensive therapy for neovascular glaucoma (NVG) by which the main goal is to complete pan-retinal photocoagulation (PRP) and the core treatment is anti-VEGF injection/anti-glaucoma operation,and to discuss the treatment strategies.Methods To design a medical treatment process for NVG.Ten eyes of 9 patients treated with comprehensive therapy including medications for decreasing intraocular pressure (IOP),combination cataract remove/vitrectomy/anti-glaucoma operation or anti-glaucoma operation alone and compete PRP after all the basis treatment.To observe IOP,visual function and anterior chamber angle neovascularization for 6-18 months follow-up (average,9.7months).Results The mean IOP was 42.30 mmHg (± 10.25) before treatment,and the mean IOP was 17.30mmHg (± 4.86) after treatment.The difference had statistic significance (P＜0.001).Visual acuity of 7 eyes was improved significantly after treatment.Iris and anterior chamber angle neovasculization of 8 eyes were regressed completely at the last follow-up.Conclusions IOP is well controlled and visual function is preserved maximum with comprehensive therapy for NVG by completing PRP and anti-VEGF/anti-glaucoma operation.
