CAJ | 학술논문

目的观察长期口服氯沙坦对高血压伴心房纤颤(房颤)患者脑卒中一级预防的效果.方法采用前瞻性随机对照研究方法,将180例高血压伴房颤患者随机分为观察组和对照组,每组90例,分别予以口服氯沙坦和美托洛尔治疗,治疗时间均为3年.观察血压、脉压变化以及脑卒中发生率和因心血管事件的病死率.结果治疗3年后,两组患者血压均显著下降(均P＜0.01).但治疗组血压波动幅度、脉压均明显降低(均P＜0.01),而对照组无明显变化(P＞0.05).观察组脑卒中发生率、心肌梗死发生率以及因心血管事件病死率分别为22.2％、10.0％和13.3％,与对照组的70.0％、40.0％和44.4％相比,差异均有统计学意义(均P＜0.01).结论氯沙坦与美托洛尔比较,降压效果相同,但对脑卒中一级预防的效果明显优于美托洛尔.
목적 관찰장기구복록사탄대고혈압반심방섬전(방전)환자뇌졸중일급예방적효과.방법 채용전첨성수궤대조연구방법,장180례고혈압반방전환자수궤분위관찰조화대조조,매조90례,분별여이구복록사탄화미탁락이치료,치료시간균위3년.관찰혈압、맥압변화이급뇌졸중발생솔화인심혈관사건적병사솔.결과 치료3년후,량조환자혈압균현저하강(균P＜0.01).단치료조혈압파동폭도、맥압균명현강저(균P＜0.01),이대조조무명현변화(P＞0.05).관찰조뇌졸중발생솔、심기경사발생솔이급인심혈관사건병사솔분별위22.2％、10.0％화13.3％,여대조조적70.0％、40.0％화44.4％상비,차이균유통계학의의(균P＜0.01).결론 록사탄여미탁락이비교,강압효과상동,단대뇌졸중일급예방적효과명현우우미탁락이.
Objective To study the effect of angiotensin Ⅱ type 1 receptor antagonist (ARB) losartan on reducing the incidence of stroke in patients which suffer from hypertension and atrial fibrillation(AF).Methods Prospective randomized analysis was used to divide one hundred and eighty hypertemion patients with atrial fibrillation into two groups.ARB treatment group was treated with losartan (n =90) and beta-blockers treatment group was treated with metoprolol ( n =90),all patients were treated for three years and followed up.Blood pressure,pulse pressure,incidence of stroke and myocardial infarction and mortality of cardiovascular events were evaluated.Results After antihypertensive treatment,blood pressure was reduced in two groups,the pulse pressure in losartan group was reduced obviously( all P ＜0.01 ).The incidence of stroke and myocardial infarction and mortality of cardiovascular events in losartan group were 22.2％,10.0％ and 13.3％,respectively,lower than that in metoprolol group 70.0％,40.0％ and 44.4％ ( all P ＜0.01 ).Conclusion Losartan reduced the incidence of stroke in the hypertension patients with AF.