CAJ | 학술논문

回顾分析2005-2009年间在我院内分泌科和心内科收治的代谢综合征(MS)患者和非MS患者的临床资料,采用多元线性回归分析Log(NT-proBNP)值与血压、血脂等指标的关系,并采用协方差分析各组间Log(NT-proBNP)值的差异.年龄、体重指数、收缩压、舒张压、胰岛素抵抗指数、甘油三酯、低密度脂蛋白胆固醇、肌酐、左房内径、左室舒张末期后壁厚度、左室射血分数为Log(NT-proBNP)值的独立预测因素;MS组患者Log(NT-proBNP)值明显低于非MS组患者(P＜0.05);高甘油三酯和体重指数、正常收缩压、舒张压和空腹血糖的MS患者Log(NT-proBNP)值均明显低于非MS患者(P＜0.05).表明MS患者NT-proBNP水平明显低于非MS患者,这可能与MS患者血脂代谢紊乱和肥胖有关.
회고분석2005-2009년간재아원내분비과화심내과수치적대사종합정(MS)환자화비MS환자적림상자료,채용다원선성회귀분석Log(NT-proBNP)치여혈압、혈지등지표적관계,병채용협방차분석각조간Log(NT-proBNP)치적차이.년령、체중지수、수축압、서장압、이도소저항지수、감유삼지、저밀도지단백담고순、기항、좌방내경、좌실서장말기후벽후도、좌실사혈분수위Log(NT-proBNP)치적독립예측인소;MS조환자Log(NT-proBNP)치명현저우비MS조환자(P＜0.05);고감유삼지화체중지수、정상수축압、서장압화공복혈당적MS환자Log(NT-proBNP)치균명현저우비MS환자(P＜0.05).표명MS환자NT-proBNP수평명현저우비MS환자,저가능여MS환자혈지대사문란화비반유관.
A retrospective analysis was made on clinical data of 230 cases of metabolic syndrome (MS) and 239 cases of non-MS admitted to department of cardiology and endocrinology of Huashan Hospital from July 2005 to August 2009.Multiple linear regression analysis was performed to assess the association between levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and potential influencing factors.Covariance analysis was used for group comparison.Multiple linear regression analysis demonstrated that age,body mass index,systolic blood pressure,diastolic blood pressure,insulin resistance index,triglyceride,low density lipoprotein-cholesterol,creatine,left atrial diameter,left ventricular posterior wall dimensions,left ventricular ejection fraction were independent predictors for plasma levels of NT-proBNP in those subjects(P ＜ 0.05).Covariance analysis showed that plasma levels of NT-proBNP in MS group were significantly lower than those in non-MS group ( P ＜ 0.05).Further analysis found that plasma levels of NT-proBNP in MS patients with high triglyceride and body mass index,but normal systolic and diastolic blood pressure,normal fasting plasma glucose were significantly lower than those in non-MS group ( P ＜ 0.05 ).The results indicate that decreased plasma levels of NT-proBNP might be related to lipids disorder and obesity of MS patients.