CAJ | 학술논문

目的了解本地区产超广谱β-内酰胺酶(ESBLs)志贺菌的检出率以及耐药情况,为临床治疗菌痢提供试验依据.方法 E-test试验进行ESBLs志贺菌的检测,改良三维试验检测AmpC酶,K-B纸片扩散法进行药敏试验,用WHONET5.4软件进行数据分析.结果 275株志贺菌中,产ESBLs志贺菌12株,检出率为4.4%,未检测出产AmpC酶菌株.产ESBLs组对第1代、第2代、第3代头孢菌素和氨曲南耐约性均明显高于非产ESBLs组,氨苄西林、氯霉素、四环素、复方新诺明耐药率在两组均有较高水平.对亚胺培南、头孢西丁、环丙沙星、庆大霉素较敏感.结论本地区ESBLs志贺菌检出率虽然较低,但已经有院内感染向社区感染转化的趋势,应引起重视,合理使用抗菌药物至关重要.
목적 료해본지구산초엄보β-내선알매(ESBLs)지하균적검출솔이급내약정황,위림상치료균리제공시험의거.방법 E-test시험진행ESBLs지하균적검측,개량삼유시험검측AmpC매,K-B지편확산법진행약민시험,용WHONET5.4연건진행수거분석.결과 275주지하균중,산ESBLs지하균12주,검출솔위4.4%,미검측출산AmpC매균주.산ESBLs조대제1대、제2대、제3대두포균소화안곡남내약성균명현고우비산ESBLs조,안변서림、록매소、사배소、복방신낙명내약솔재량조균유교고수평.대아알배남、두포서정、배병사성、경대매소교민감.결론 본지구ESBLs지하균검출솔수연교저,단이경유원내감염향사구감염전화적추세,응인기중시,합리사용항균약물지관중요.
Objective To investigate the detection rate and drug resistance of extended-spectrum β-lactamases (ESBLs)-producing Shigella in the district, in order to provide a guidance to clinical ra-tional use of antibiotics. Methods ESBLs were detected by E-test, and AmpC was detected by the modified three-dimensional test; disc diffusion test (K-B method) was used to study the drug resist- ance of Shigella isolated from clinical specimens. The date analysis was performed with WHONET5.4 software. Results In 275 strains of Shigella,12 strains (4.4%) of ESBLs-producing Shigella were de-tected consider ESBLs, and no AmpC-producing strain was found in Shigella. The resistance rate of ESBLs-producing strains to first,second and third-generation cephalosporins as well as aztreonam was respectively significantly higher than that of ESBLs non-producing strains, but both of them were high sensitive to imipenem,cefoxitin,ciprofloxacin and gentamiein. Conclusion The positive rate of ESBLs-producing Shigella stains is lower in the district, but the trend of nosocomial infection to community in-fection should be paid more attention to. It is vital to use antibiotics rationally.