CAJ | 학술논문

目的:研究模拟胃癌根治术后经腹腔动脉行介入化疗5-氟脲嘧啶-2'-脱氧核苷(floxuridine,FUDR)的药物动力学效应.方法:10头健康幼猪先施以模拟胃癌根治术,于术后2周将其随机分成2组,第1组行腹腔动脉介入化疗(CAI),第2组行全身性静脉化疗(SC).采用高效液相色谱(HPLC)法测定标本中FUDR的浓度.结果:CAI组中的吻合口胃壁组织、肝脏、胰腺及结肠系膜中,FUDR的AUC0-49和Cmax明显高于SC组;注药后60 min,FUDR的平均浓度在部分胃周淋巴结中也明显高于SC组;在心脏和肾脏中则两组无显著差异.结论:术后经腹腔动脉行介入化疗后,FUDR的药动学效应明显优于行全身性静脉化疗者,且未见毒副作用的增加.本实验为临床胃癌根治术后选择经腹腔动脉介入化疗治疗或预防肿瘤复发、转移,并提高疗效提供了实验依据.
목적:연구모의위암근치술후경복강동맥행개입화료5-불뇨밀정-2'-탈양핵감(floxuridine,FUDR)적약물동역학효응.방법:10두건강유저선시이모의위암근치술,우술후2주장기수궤분성2조,제1조행복강동맥개입화료(CAI),제2조행전신성정맥화료(SC).채용고효액상색보(HPLC)법측정표본중FUDR적농도.결과:CAI조중적문합구위벽조직、간장、이선급결장계막중,FUDR적AUC0-49화Cmax명현고우SC조;주약후60 min,FUDR적평균농도재부분위주림파결중야명현고우SC조;재심장화신장중칙량조무현저차이.결론:술후경복강동맥행개입화료후,FUDR적약동학효응명현우우행전신성정맥화료자,차미견독부작용적증가.본실험위림상위암근치술후선택경복강동맥개입화료치료혹예방종류복발、전이,병제고료효제공료실험의거.
Objective To investigate the pharmacokinetics of floxuridine (FUDR) when administered postoperatively via the celiac axis in experimental animals. Methods Ten healthy prepubertal pigs underwent first radical gastrectomy, then were randomly divided into two groups (each n=5): the one group in which the drug was given via the celiac artery (CAI). and the other in which the drug was administered systemically through a vein (SC). High performance liquid chromatography (HPLC) was applied to determine the concentration of FUDR in the peripheral blood, tissues surrounding the gastric anastomosis, stomach-neighboring organs and tissues as well as in the related lymph nodes. Results The AUC0-49 and Cmax of FUDR in the tissues neigboring the gastric anastomosis in the liver, pancreas colic mesentery and the Cmax of FUDR in the lymph nodes along the celiac artery and the middle colic vessels, were significantly higher in the CAI group compared with the SC group. There were no significant difference in terms of the Cmax of FUDR in the heart and kidney between the 2 groups. Conclusions A higher concentration of FUDR in the tissues surrounding the gastric anastomosis and in the other neighboring organs and tissues can be achieved in the CAl group, indicating that a better outcome in the treatment and prevention of metastases and recurrence can be obtained through the use of CAI than the SC and without additional toxic reaction.