国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2012年
2期
121-123,封3
,共4页
张敏%周莉%张开贤%李苓%石存
張敏%週莉%張開賢%李苓%石存
장민%주리%장개현%리령%석존
食管肿瘤%放射治疗计划,计算机辅助%放射疗法,调强适形%病例对照研究
食管腫瘤%放射治療計劃,計算機輔助%放射療法,調彊適形%病例對照研究
식관종류%방사치료계화,계산궤보조%방사요법,조강괄형%병례대조연구
Esophageal neoplasms%Radiotherapy planning,computer-assisted%Radiation therapy,intensity-modulated%Case-control studies
目的 分析中下段食管癌放疗中5野调强计划与7野调强计划的差异,寻找布野最佳方案.方法 分别为接受调强放射治疗的12例中下段食管癌患者设计5野调强计划与7野调强计划,计划设计中要求95％的计划靶体积达到处方剂量.在每个病例中,分别比较两种计划的剂量体积直方图统计数据、剂量均匀指数、剂量适形指数.结果 两种方案中,7野调强计划的靶区剂量适形度较好(t=2.681,P＜0.05)；两种方案的剂量均匀指数、脊髓受照剂量、心脏受照剂量之间的差异无统计学意义；5野调强计划的双肺V5、V10、V15较低(t=-7.938、-12.055和4.859,P均＜0.05).结论 在中下段食管癌放疗中,与7野调强计划相比,5野调强计划可以减少肺部的低剂量受照体积,同时提供可以接受的计划靶体积适形度,有助于减少肺部辐射损伤的发生概率,改善患者生存质量,值得在临床工作中推广应用.
目的 分析中下段食管癌放療中5野調彊計劃與7野調彊計劃的差異,尋找佈野最佳方案.方法 分彆為接受調彊放射治療的12例中下段食管癌患者設計5野調彊計劃與7野調彊計劃,計劃設計中要求95％的計劃靶體積達到處方劑量.在每箇病例中,分彆比較兩種計劃的劑量體積直方圖統計數據、劑量均勻指數、劑量適形指數.結果 兩種方案中,7野調彊計劃的靶區劑量適形度較好(t=2.681,P＜0.05)；兩種方案的劑量均勻指數、脊髓受照劑量、心髒受照劑量之間的差異無統計學意義；5野調彊計劃的雙肺V5、V10、V15較低(t=-7.938、-12.055和4.859,P均＜0.05).結論 在中下段食管癌放療中,與7野調彊計劃相比,5野調彊計劃可以減少肺部的低劑量受照體積,同時提供可以接受的計劃靶體積適形度,有助于減少肺部輻射損傷的髮生概率,改善患者生存質量,值得在臨床工作中推廣應用.
목적 분석중하단식관암방료중5야조강계화여7야조강계화적차이,심조포야최가방안.방법 분별위접수조강방사치료적12례중하단식관암환자설계5야조강계화여7야조강계화,계화설계중요구95％적계화파체적체도처방제량.재매개병례중,분별비교량충계화적제량체적직방도통계수거、제량균균지수、제량괄형지수.결과 량충방안중,7야조강계화적파구제량괄형도교호(t=2.681,P＜0.05)；량충방안적제량균균지수、척수수조제량、심장수조제량지간적차이무통계학의의；5야조강계화적쌍폐V5、V10、V15교저(t=-7.938、-12.055화4.859,P균＜0.05).결론 재중하단식관암방료중,여7야조강계화상비,5야조강계화가이감소폐부적저제량수조체적,동시제공가이접수적계화파체적괄형도,유조우감소폐부복사손상적발생개솔,개선환자생존질량,치득재림상공작중추엄응용.
Objective To analyze the difference between five-field plan and seven-field plan in intensity modulated radiation therapy for patients with mid- and distal-esophageal carcinoma,and to find out the optimal beam arrangement.Methods Five-field plan and seven-field plan were designed for each of 12 patients with mid- and distal-esophageal carcinoma.95％ of planning target volume was required to achieve prescription dose.Dose-volume histograms statistics,dose uniformity,and dose conformity in every patient were compared respectively.Results Superior dose conformity for planning target volume was shown in seven-ficld plan (t=2.681,P＜0.05).Difference was not significant between uniformity in seven-field plan and that in five-field plan.Difference was not significant between doses received by organs at risk,such as spinal cord and heart,in seven-field plan and those in five-field plan.V5,V10,V15 of lungs in five-field plan were lower significantly than those in seven-field plan (t=-7.938,-12.055 and -4.859,all P＜0.05).Conclusions For patients with thoracic esophageal carcinoma treated by intensity modulate radiation therapy,compared with 7-fielded plan,the volume of lungs with lower dose could be reduced on the premise of acceptable planning target volume coverage by the application of five-plan.Therefore,radiation-induced lung injury occurrence probability would be reduced,and the patient's quality of life would be improved.Five-field plan would be worth applying in the clinical work.
