CAJ | 학술논문

丙肝肝炎后肝移植病人均伴随不同程度的丙型肝炎病毒(HCV)复发,其发病机制因疾病的不同阶段而不同.影响复发的因素包括HCV基因型、病毒载量、供体和受体HLA匹配情况、复发的时间、供体的年龄等,而免疫抑制剂的使用是最重要的影响因素.治疗的效果通过持续病毒学应答来评价.目前认为聚二乙醇干扰素联合利巴韦林是治疗慢性丙型肝炎最好的选择和最佳的治疗方案.
병간간염후간이식병인균반수불동정도적병형간염병독(HCV)복발,기발병궤제인질병적불동계단이불동.영향복발적인소포괄HCV기인형、병독재량、공체화수체HLA필배정황、복발적시간、공체적년령등,이면역억제제적사용시최중요적영향인소.치료적효과통과지속병독학응답래평개.목전인위취이을순간우소연합리파위림시치료만성병형간염최호적선택화최가적치료방안.
Different degrees of HCV re-infection exist in patients with hepatitis C after liver transplantation. Its pathogenesis is different according to different phases of the disease. Factors affecting its recurrence include HCV gene type, viral load, HLA matching between donor and recipient, time of recurrence, donor's age and so on, in which the application of immunosuppressants is the most important influencing factor. The virological response can be used to evaluate the effects of treatment. Now, it is widely accepted that the best choice and therapeutic plan is Pegy interferon alfa-2a/2b combined with Ribavirin.