CAJ | 학술논문

为研究聚乙二醇基氯硝柳胺衍生物体外抑制钉螺乙酰胆碱酯酶的活性,测定了氯硝柳胺衍生物抑制钉螺乙酰胆碱酯酶的半数抑制浓度IC_(50).结果表明:随着氯硝柳胺衍生物浓度的增加,对乙酰胆碱酯酶活性的抑制作用逐渐增强;随着聚乙二醇基链长的增加,药物对乙酰胆碱酯酶抑制活性依次减弱.
위연구취을이순기록초류알연생물체외억제정라을선담감지매적활성,측정료록초류알연생물억제정라을선담감지매적반수억제농도IC_(50).결과표명:수착록초류알연생물농도적증가,대을선담감지매활성적억제작용축점증강;수착취을이순기련장적증가,약물대을선담감지매억제활성의차감약.
The concentrations causing 50% inhibition ( IC_(50)) of acetylcholinesterase (AChE) activity by niclosamide derivatives containing polyethylene glycol groups were determined in order to study the effects of niclosamide derivatives on AChE of oncomela-nia snail in vitro. Test results showed that an increasing drugs concentration would lead to the enhancement of inhibitory effects. With an increasing chain length of polyethylene glycol group linked on niclosamide,the inhibitory effects weakened.