CAJ | 학술논문

合成了5个新的二乙基锡N-[(2-氧苯基)亚甲基]甘氨酸酯(CH3CH2)2Sn(2-O-3-X-5-YC6H2CH=NCH2COO)(X,Y=H,H,1;H,Cl,2;H,Br,3;Cl,Cl,4;Br,Br,5),利用元素分析、IR、1H和129Sn NMR表征了其结构.通过X-射线单晶衍射测定了1和4的晶体结构.化合物1的晶体属单斜晶系,P21空间群;化合物4的晶体属三斜晶系,P1空间群.2个化合物均为由羧基桥联形成的[Sn3O6C3]十二元大环三聚体结构,锡原子的配位构型为六配位[SnC2NO3]畸变八面体.生物活性测试结果表明,化合物5对3种人癌细胞HeLa、CoLo205和MCF-7及大肠杆菌均有抑制活性.
합성료5개신적이을기석N-[(2-양분기)아갑기]감안산지(CH3CH2)2Sn(2-O-3-X-5-YC6H2CH=NCH2COO)(X,Y=H,H,1;H,Cl,2;H,Br,3;Cl,Cl,4;Br,Br,5),이용원소분석、IR、1H화129Sn NMR표정료기결구.통과X-사선단정연사측정료1화4적정체결구.화합물1적정체속단사정계,P21공간군;화합물4적정체속삼사정계,P1공간군.2개화합물균위유최기교련형성적[Sn3O6C3]십이원대배삼취체결구,석원자적배위구형위륙배위[SnC2NO3]기변팔면체.생물활성측시결과표명,화합물5대3충인암세포HeLa、CoLo205화MCF-7급대장간균균유억제활성.
Five new diethyltin N-[(2-oxyphenyl)methylene]glycinates,(CH3CH2)2Sn(2-O-3-X-5-YC6H2CH=NCH2 COO) (X,Y=H,H,1;H,Cl,2;H,Br,3;Cl,Cl,4;Br,Br,5),have been prepared and characterized by elemental analysis,IR,1H and 119Sn NMR spectra.The crystal structures of 1 and 4 have been determined.The crystal for 1 belongs to monoclinic space group P21,and the crystal for 4 belongs to triclinic space group P1.The two compounds have a 12-membered macrocyelic structure with a trimerie [Sn3O6C3] core.Each tin atom is six-coordinated in distorted [SnC2NO3] octahedron geometry.Bioassay results show that the compound 5 has in vitro anti-tumor activity against three human turnout cell lines,HeLa,CoLo205 and MCF-7 and anti-bacterial activity against E.coli.CCDC:729956,1;729957,4.