CAJ | 학술논문

目的探讨腺病毒介导凋亡素基因联合阿霉素(ADM)与顺铂(CDDP)对种植性肝癌的治疗.方法建立c57BL/6小鼠皮下荷肝细胞癌模型(n=64),计算成瘤率,观察肿瘤内注射含凋亡素基因的重组腺病毒、ADM及CDDP后种植瘤的体积变化、毒副作用和组织学变化,同时计算抑瘤率.结果在治疗7d后腺病毒AdAFPvp3联合ADM与CDDP治疗组的种植瘤体积、重量均显著低于对照组,比较差异均具有统计学意义,在治疗期间没有观察到毒副作用.结论携带凋亡素基因的重组腺病毒联合ADM与CDDP对肝细胞癌具有治疗作用.
목적 탐토선병독개도조망소기인연합아매소(ADM)여순박(CDDP)대충식성간암적치료.방법 건립c57BL/6소서피하하간세포암모형(n=64),계산성류솔,관찰종류내주사함조망소기인적중조선병독、ADM급CDDP후충식류적체적변화、독부작용화조직학변화,동시계산억류솔.결과 재치료7d후선병독AdAFPvp3연합ADM여CDDP치료조적충식류체적、중량균현저저우대조조,비교차이균구유통계학의의,재치료기간몰유관찰도독부작용.결론 휴대조망소기인적중조선병독연합ADM여CDDP대간세포암구유치료작용.
Objective To study the therapeutic effect adenovirus-mediated apoptin gene transfer combined with ADM and CDDP on hepatocellular carcinoma in mice. Methods In c57BL/6 mice bearing hepatocellular carcinoma, the changes of tumor volume, histomorphology, tumor inhibition rate and the side effects were observed after intratumoral injection of adenovirus containing apoptin gene and ADM and CDDP. Results Seven days after the treatment, the mean volume of the tumor in the mice receiving intratumoral apoptin-containing adenovirus injection combined with ADM and CDDP reduced significantly as compared with that in mice treated with adenovirus vehicle and control group. The tumor inhibition rate in the combined treatment group was 90.13%, significantly higher than that in the control group. No adverse effect of the treat was observed in the course of the experiment. Conclusion The adenoviras vectors containing apoptin gene combined with ADM and CDDP may serve a safe treatment of hepatocellular carcinoma.