南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2011年
12期
1963-1967
,共5页
柯晓云%莒瑞红%张家庆%陈慧%魄二霞%陈晓虹
柯曉雲%莒瑞紅%張傢慶%陳慧%魄二霞%陳曉虹
가효운%거서홍%장가경%진혜%백이하%진효홍
早产儿视网膜病变%发病率%相关因素
早產兒視網膜病變%髮病率%相關因素
조산인시망막병변%발병솔%상관인소
retinopathy%prematurity%incidence%risk factors
目的 评估严重早产儿视网膜病变(ROP)的发生率及相关危险因素分析.方法 回顾性分析2008年5月～2011年5月期间我院957例早产儿的临床资料和出生后4-6周或矫正胎龄32周行ROP筛查的结果.结果 957例早产儿中,发生不同程度ROP病变者86例(8.99％),其中轻度ROP 60例(6.27％),重度ROP26例(2.72％).发生重度ROP病变的早产儿平均出生体质量为(1420.40±328.6)g,平均出生胎龄为(29.88±1.67)周,而轻度病变患儿的平均出生体质量和出生胎龄分别为(1593.28±339.3)g和(31.78±2.53)周,两组相比具有显著差异(P＜0.005).各因素中,出生胎龄、出生体质量、出生后1min、5 min Apgar评分、输血次数、呼吸暂停史及视网膜出血对严重ROP的发生有影响(P值分别为0.001、0.035、0.001、0.005、0.032、0.04、0.000,a=0.05).经logistic回归分析,仅出生胎龄与网膜出血与严重ROP的发生有相关性(OR=0.353,95％CI 0.163-0.763,P=0.008; OR=26.133,95％CI 3.042-224.501,P=0.035).结论 严重ROP发病率呈下降趋势并且更多发生在较成熟的早产儿中,受累患儿具有第一次流行的特征.出生胎龄、网膜出血都是预测严重ROP发生的相关因素.
目的 評估嚴重早產兒視網膜病變(ROP)的髮生率及相關危險因素分析.方法 迴顧性分析2008年5月～2011年5月期間我院957例早產兒的臨床資料和齣生後4-6週或矯正胎齡32週行ROP篩查的結果.結果 957例早產兒中,髮生不同程度ROP病變者86例(8.99％),其中輕度ROP 60例(6.27％),重度ROP26例(2.72％).髮生重度ROP病變的早產兒平均齣生體質量為(1420.40±328.6)g,平均齣生胎齡為(29.88±1.67)週,而輕度病變患兒的平均齣生體質量和齣生胎齡分彆為(1593.28±339.3)g和(31.78±2.53)週,兩組相比具有顯著差異(P＜0.005).各因素中,齣生胎齡、齣生體質量、齣生後1min、5 min Apgar評分、輸血次數、呼吸暫停史及視網膜齣血對嚴重ROP的髮生有影響(P值分彆為0.001、0.035、0.001、0.005、0.032、0.04、0.000,a=0.05).經logistic迴歸分析,僅齣生胎齡與網膜齣血與嚴重ROP的髮生有相關性(OR=0.353,95％CI 0.163-0.763,P=0.008; OR=26.133,95％CI 3.042-224.501,P=0.035).結論 嚴重ROP髮病率呈下降趨勢併且更多髮生在較成熟的早產兒中,受纍患兒具有第一次流行的特徵.齣生胎齡、網膜齣血都是預測嚴重ROP髮生的相關因素.
목적 평고엄중조산인시망막병변(ROP)적발생솔급상관위험인소분석.방법 회고성분석2008년5월～2011년5월기간아원957례조산인적림상자료화출생후4-6주혹교정태령32주행ROP사사적결과.결과 957례조산인중,발생불동정도ROP병변자86례(8.99％),기중경도ROP 60례(6.27％),중도ROP26례(2.72％).발생중도ROP병변적조산인평균출생체질량위(1420.40±328.6)g,평균출생태령위(29.88±1.67)주,이경도병변환인적평균출생체질량화출생태령분별위(1593.28±339.3)g화(31.78±2.53)주,량조상비구유현저차이(P＜0.005).각인소중,출생태령、출생체질량、출생후1min、5 min Apgar평분、수혈차수、호흡잠정사급시망막출혈대엄중ROP적발생유영향(P치분별위0.001、0.035、0.001、0.005、0.032、0.04、0.000,a=0.05).경logistic회귀분석,부출생태령여망막출혈여엄중ROP적발생유상관성(OR=0.353,95％CI 0.163-0.763,P=0.008; OR=26.133,95％CI 3.042-224.501,P=0.035).결론 엄중ROP발병솔정하강추세병차경다발생재교성숙적조산인중,수루환인구유제일차류행적특정.출생태령、망막출혈도시예측엄중ROP발생적상관인소.
Objective To evaluate the incidence and risk factors for severe retinopathy of prematurity (ROP) in preterm infants.Methods Between May,2008 and May,2011,a total of 957 preterm infants at 4-6 weeks of chronological age or 32 weeks of postmenstrual age underwent retinal evaluation by RetCamⅡ in our center,and the data of infants with ROP in any stage were analyzed.Results Among the 957 preterm infants,we found 86 (8.99％) infants to have ROP in different stages,including 60(6.27％) with mild ROP and 26 (2.72％) with severe ROP.The birth weight and gestational age of the infants with severe ROP averaged 1 420.40+328.64 g and 29.88+1.67 weeks,as compared to 1 593.28±339.30 g and 31.78±2.53 weeks in those with mild ROP,respectively,showing a significant difference between the two groups (P＜0.005).The significant variables for severe ROP included gestational age (P=0.001),birth weight (P=0.035),1 min Apgar score (P=0.001),5 min Apgar score (P=0.005),number of blood transfusions (P=0.032),and the presence of apnea (P=0.04) and retinal hemorrhage (P=0.000).Gestational age and retinal hemorrhage were the independent risk factors for severe ROP (OR=0.353,95％CI 0.163-0.763,P=0.008; OR=26.133,95％CI 3.042-224.501,P=0.035).Conclusion Severe (R)OP tends to have a decreasing incidence and occurs more often in more mature preterm infants.The affected infants have the characteristics of the first epidemics.Gestational age and retinal hemorrhage are independent predictive factors for severe ROP.
