国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2012年
9期
686-689
,共4页
低温,人工%脑梗死%组织型纤溶酶原激活物%纤溶酶原激活物抑制物1
低溫,人工%腦梗死%組織型纖溶酶原激活物%纖溶酶原激活物抑製物1
저온,인공%뇌경사%조직형섬용매원격활물%섬용매원격활물억제물1
Hypothermia,Induced%Cerebral Infarction%Tissue Plasminogen Activator%Plasminogen Activator Inhibitor
目的 探讨亚低温治疗对大面积脑梗死(massive cerebral infarction,MCI)患者血浆组织型纤溶酶原激活物(tissue-type plasminogen activator,tPA)和纤溶酶原激活物抑制物-1(plasminogen activator inhibitor-1,PAI-1)的影响.方法 MCI患者随机分为常规治疗组和亚低温治疗组,后者在常规治疗基础上在入院后立即接受局部亚低温治疗48 h.分别于入院时和亚低温治疗48 h时采用酶联免疫吸附法检测血浆tPA和PAI-1.比较两组一般资料以及治疗前、后血浆tPA和PAI-1水平.结果 共纳入46例患者,其中常规治疗组26例,亚低温治疗组20例.两组患者治疗前一般临床资料以及tPA[(134.5± 45.7)pg/ml 对 (132.7± 40.3)pg/ml;t=-0.752,P=0.481]和PAI-1[(206.4±42.3)pg/ml对(207.0 ±42.0)pg/ml;t =0.642,P=0.745]均无显著差异,而亚低温治疗组在亚低温治疗48 h时血浆tPA[(80.98± 34.64)pg/ml对(110.1±32.7)pg/ml; t=3.462,P=0.013]和PAI-1[(145.40 ±45.29) pg/ml对(174.2 ±38.0) pg/ml;t =4.854,P=0.034]水平均显著低于常规治疗组.结论 亚低温治疗能降低MCI患者血浆tPA和PAI-1水平,可能与低温治疗的神经保护作用有关.
目的 探討亞低溫治療對大麵積腦梗死(massive cerebral infarction,MCI)患者血漿組織型纖溶酶原激活物(tissue-type plasminogen activator,tPA)和纖溶酶原激活物抑製物-1(plasminogen activator inhibitor-1,PAI-1)的影響.方法 MCI患者隨機分為常規治療組和亞低溫治療組,後者在常規治療基礎上在入院後立即接受跼部亞低溫治療48 h.分彆于入院時和亞低溫治療48 h時採用酶聯免疫吸附法檢測血漿tPA和PAI-1.比較兩組一般資料以及治療前、後血漿tPA和PAI-1水平.結果 共納入46例患者,其中常規治療組26例,亞低溫治療組20例.兩組患者治療前一般臨床資料以及tPA[(134.5± 45.7)pg/ml 對 (132.7± 40.3)pg/ml;t=-0.752,P=0.481]和PAI-1[(206.4±42.3)pg/ml對(207.0 ±42.0)pg/ml;t =0.642,P=0.745]均無顯著差異,而亞低溫治療組在亞低溫治療48 h時血漿tPA[(80.98± 34.64)pg/ml對(110.1±32.7)pg/ml; t=3.462,P=0.013]和PAI-1[(145.40 ±45.29) pg/ml對(174.2 ±38.0) pg/ml;t =4.854,P=0.034]水平均顯著低于常規治療組.結論 亞低溫治療能降低MCI患者血漿tPA和PAI-1水平,可能與低溫治療的神經保護作用有關.
목적 탐토아저온치료대대면적뇌경사(massive cerebral infarction,MCI)환자혈장조직형섬용매원격활물(tissue-type plasminogen activator,tPA)화섬용매원격활물억제물-1(plasminogen activator inhibitor-1,PAI-1)적영향.방법 MCI환자수궤분위상규치료조화아저온치료조,후자재상규치료기출상재입원후립즉접수국부아저온치료48 h.분별우입원시화아저온치료48 h시채용매련면역흡부법검측혈장tPA화PAI-1.비교량조일반자료이급치료전、후혈장tPA화PAI-1수평.결과 공납입46례환자,기중상규치료조26례,아저온치료조20례.량조환자치료전일반림상자료이급tPA[(134.5± 45.7)pg/ml 대 (132.7± 40.3)pg/ml;t=-0.752,P=0.481]화PAI-1[(206.4±42.3)pg/ml대(207.0 ±42.0)pg/ml;t =0.642,P=0.745]균무현저차이,이아저온치료조재아저온치료48 h시혈장tPA[(80.98± 34.64)pg/ml대(110.1±32.7)pg/ml; t=3.462,P=0.013]화PAI-1[(145.40 ±45.29) pg/ml대(174.2 ±38.0) pg/ml;t =4.854,P=0.034]수평균현저저우상규치료조.결론 아저온치료능강저MCI환자혈장tPA화PAI-1수평,가능여저온치료적신경보호작용유관.
Objective To investigate the effect of mild hypothermia therapy on plasma tissue-type plasminogen activator (tPA)/plasminogen activator inhibitor-1 (PAI-1) in patients with massive cerebral infarction (MCI).Methods The patients with MCI were randomly divided into the conventional therapy group and the mild hypothermia therapy group.On the basis of conventional therapy,the latter received local mild hypothermia therapy for 48 hours immediately after admission.Enzyme-linked immunosorbent assay was used to detect plasma tPA and PAI-1 at admission and at 48 hours after mild hypothermia,respectively.The general information and the tPA and PAI-1 levels before and after treatment in both groups were compared.Results A total of 46 patients with MCI were included.There were 26 and 20 patients in the conventional therapy group and the mild hypothermia therapy group,respectively.There were no significant differences in the general information,the tPA and PAI-1 levels before and after treatment in both groups,and the levels of plasma tPA (80.98 ± 34.64 pg/mL vs.110.1 ± 32.7 pg/mL; t =3.462,P =0.013) and PAI-1 (145.40 ± 45.29 pg/mL vs.174.2 ± 38.0 pg/mL; t =4.854,P =0.034) at 48 hours of mild hypothermia therapy in the mild hypothermia therapy group were significantly lower than those in the conventional therapy group.Conclusions Mild hypothermia therapy may decrease the plasma tPA and PAI-1 levels in patients with MCI,and it may be associated with the neuroprotective effect of hypothermia therapy.
