CAJ | 학술논문

目的体外实验研究国产非黏附性液体栓塞材料次乙烯醇异分子聚合物(EVAL)的理化性质,以确定其是否适合脑血管畸形(AVM)的栓塞治疗.方法用旋转黏度计在不同温度下(25℃和37℃),测定不同浓度的EVAL分别含EVOH 6%、8%和20%的黏度.将不同浓度(6%和8%)的EVAL在生理盐水液面以下约1cm处缓慢推出,测定其沉淀时间.用电子显微镜放大不同倍数,观察EVAL在体外析出后形成固体的超微结构.结果不同浓度的EVAL黏度有明显差别,随着EVAL浓度的增加黏度也增加.温度对EVAL的黏度有较大的影响,随着温度的升高黏度是下降的.沉淀时间则不受EVAL浓度和温度的影响.EVAL在体外析出后形成的同体在低倍电子显微镜下的结构呈海绵状,在高倍电子显微镜下呈带网的片状结构.结论不同浓度的EVAL具有不同的理化性质.因而适合不同类型的脑AVM的栓塞.
목적 체외실험연구국산비점부성액체전새재료차을희순이분자취합물(EVAL)적이화성질,이학정기시부괄합뇌혈관기형(AVM)적전새치료.방법 용선전점도계재불동온도하(25℃화37℃),측정불동농도적EVAL분별함EVOH 6%、8%화20%적점도.장불동농도(6%화8%)적EVAL재생리염수액면이하약1cm처완만추출,측정기침정시간.용전자현미경방대불동배수,관찰EVAL재체외석출후형성고체적초미결구.결과 불동농도적EVAL점도유명현차별,수착EVAL농도적증가점도야증가.온도대EVAL적점도유교대적영향,수착온도적승고점도시하강적.침정시간칙불수EVAL농도화온도적영향.EVAL재체외석출후형성적동체재저배전자현미경하적결구정해면상,재고배전자현미경하정대망적편상결구.결론 불동농도적EVAL구유불동적이화성질.인이괄합불동류형적뇌AVM적전새.
Objective Study the physiochemieal characteristics of ethylene vinyl alcohol copolymer (EVAL)mixtures(a non-adhesive fluid embolism matedal made in China)in vitro to determine the feasibility of the mixtures in endbolization of cerebral arteriovenous malformations.Methods In various EVOH)were assayed by the rotational viscosimeter.The EVAL solutions of various concentrations(contain 6%and 8%EVOH)were pushed out slowly under 1cm of physiological saline liquid level to assay the precipitation times.With the electronic microscope.the uhm-structure of EVAL solid in vitro was observed.Results The visoosities of different mixtures difiered significantly.Along with the increase of EVAL concentrations,the viscosity also raised.The temperature of different mixtures differed signiticanfly.Along with increase of EVAL temperature,the viscosity decreased.The precipitation times were not affected signifieandy by the concentration and tempergture,The EVAL solutions might precipitate in vitro and become solid.With the low power electronic microscope,the EVAL solid Was found to like sponge,and with the high power electronic microscope,the EVAL solid was found to like a laminar structure with many meshes.Conclusions Because of their different physiochemical properties,the various EVAL mixtures are suitable for the embolization of difierent types of cerebral arteriovenous malformations.