CAJ | 학술논문

目的观察不同剂量辛伐他汀对生殖激素水平的影响.方法将健康sD大鼠雌性随机分为对照组25只,实验组100只分为A、B、C、D四个亚组,雄性随机分为对照组25只,实验组75只分为A、B、C三个亚组.实验组雌鼠每日分别给予HMG-COA还原酶抑制剂辛伐他汀1、6、10、60 mg/kg体重,实验组雄鼠每日分别给予HMG-COA还原酶抑制剂辛伐他汀1、6、10 mg/kg体重,用生理盐水溶解灌服.对照组每日仅用生理盐水灌服.持续8周后雌鼠检测卵泡刺激素(FSH)、黄体生成素(LH)、血清雌二醇(E2)、睾酮(T)的水平.雄鼠检测血清高密度脂蛋白(HDL)、血清低密度脂蛋白(LDL)、睾酮(T)的水平.结果各实验组雄鼠HDL值较对照组明显升高(P＜0.01),LDL和T值则与对照组差异元统计学意义(P＞0.05),各实验组雌鼠的FSH值、LH值、E2值、T值与对照组比较差异无统计学意义(P＞0.05).结论辛伐他汀能有效提高血管保护性脂蛋白HDL的水平而对维持生理作用的生殖激素影响不大,是一种有效、安全的降脂药.
목적 관찰불동제량신벌타정대생식격소수평적영향.방법 장건강sD대서자성수궤분위대조조25지,실험조100지분위A、B、C、D사개아조,웅성수궤분위대조조25지,실험조75지분위A、B、C삼개아조.실험조자서매일분별급여HMG-COA환원매억제제신벌타정1、6、10、60 mg/kg체중,실험조웅서매일분별급여HMG-COA환원매억제제신벌타정1、6、10 mg/kg체중,용생리염수용해관복.대조조매일부용생리염수관복.지속8주후자서검측란포자격소(FSH)、황체생성소(LH)、혈청자이순(E2)、고동(T)적수평.웅서검측혈청고밀도지단백(HDL)、혈청저밀도지단백(LDL)、고동(T)적수평.결과 각실험조웅서HDL치교대조조명현승고(P＜0.01),LDL화T치칙여대조조차이원통계학의의(P＞0.05),각실험조자서적FSH치、LH치、E2치、T치여대조조비교차이무통계학의의(P＞0.05).결론 신벌타정능유효제고혈관보호성지단백HDL적수평이대유지생리작용적생식격소영향불대,시일충유효、안전적강지약.
Objective To investigate effects of Simvastatin on the levels of genesial hormones.Methods Twenty-five health SD female-rats served as control group and 100 rats of the test group into A、B、C、D groups at random.Also,we used the SD male rats in the salne way,25 mice for the control group and 75 ones for the test group which divided into A,B,C groups.Test group of female-mice were fed Simvastatin which is HMG-CoA reductase inhibitor according to 1、6、10、60 mg/kg.And test group of malemice were fed according to 1、6、10 mg/kg.Both of two groups wero drenched by Simvastatin dissolving in N.S.Accordingly,the rats of control groups were only fed N.S.everyday.Then,we measured the valLles of FSH、LH、E2 and T for the female-rats and HDL、LDL、T valUes forthe male-rats after 8 weeks.Results Compared with the health group of male-rats,the HDL values of the test groups obviously rise(P＜0.01)and the LDL,T values make no statistics meaning(P＞0.05).Accordingly,the helth group of female-rats have nearly the same datas with the control group,including FSH,LH,E2,T.Conclusion Simvastatin is an effective safe hypolipidemic which impaet genesial hormone littile