代谢综合征X%脂联素%统计学%非参数
代謝綜閤徵X%脂聯素%統計學%非參數
대사종합정X%지련소%통계학%비삼수
Metabolic syndrome X%Adiponectin%Statistics,nonparametric
目的 探讨血清脂联素水平与代谢综合征(metabolic syndrome,MS)各组分的相关性.方法 采用整群随机抽样的方法,抽取上海市的两个城区,经调查和体检,筛选出MS患者235例.通过对MS患者的脂联素水平与MS各组分(腰围、血压、血糖、血脂)相关性分析及主成分回归分析,初步探讨血清脂联素水平与MS各组分的关系.结果 男性脂联素水平为(2.82±1.73)μg/ml低于女性的(5.12±3.51)μg/ml,差异有统计学意义(Z=-5.25,P=0.00).脂联素水平[(4.38±3.23)μg/ml]与腹部肥胖相关,其与腰围[(93.37±7.76)cm]的spearrnan秩相关系数为rs=-0.18(tt=-2.79,P=0.01);与腰臀比(0.91±0.05)的spearman秩相关系数为rs=-0.28(tr=-4.44,P=0.00),而与人体质量指数(body mass index,BMI)[(26.85±3.10)ks/m2]无显著相关性(rs=-0.10,tr=-1.45,P=0.15).脂联素与胰岛素抵抗相关指标关系密切,包括空腹血糖[(5.48±1.72)mmol/L](rs=-0.13,tr=-2.00,P=0.05)、空腹胰岛素[(11.52±5.34)mU/L](rs=-0.15,tr=-2.31,P=0.02)、稳态模式评估法的胰岛素抵抗指数(HOMA-IR)(2.90±2.07)(rs=-0.17,tr=-2.63,P=0.01)及甘油三酯水平[(2.11±1.24)mmol/L](rs=-0.24,tr=-3.77,P=0.00).脂联素与总胆固醇水平[(5.01±1.19)mmol/L](rs=-0.05,tr=-0.78,P=0.44)、高密度脂蛋白胆固醇(HDL-C)[(1.21±0.32)mmol/L](rs=0.06,tr=0.93,P=0.36)、收缩压[(131.40±14.93)nun Hg,1 nun Hg=0.133 kPa](rs=-0.02,tr=-0.34,P=0.73)及舒张压[(86.77±9.14)mm Hg](rs=-0.02,tr=-0.27,P=0.78)无显著相关性.结论 MS患者血清脂联素水平与腹部肥胖及胰岛素抵抗相关指标呈负相关,而与血压未见直接联系.
目的 探討血清脂聯素水平與代謝綜閤徵(metabolic syndrome,MS)各組分的相關性.方法 採用整群隨機抽樣的方法,抽取上海市的兩箇城區,經調查和體檢,篩選齣MS患者235例.通過對MS患者的脂聯素水平與MS各組分(腰圍、血壓、血糖、血脂)相關性分析及主成分迴歸分析,初步探討血清脂聯素水平與MS各組分的關繫.結果 男性脂聯素水平為(2.82±1.73)μg/ml低于女性的(5.12±3.51)μg/ml,差異有統計學意義(Z=-5.25,P=0.00).脂聯素水平[(4.38±3.23)μg/ml]與腹部肥胖相關,其與腰圍[(93.37±7.76)cm]的spearrnan秩相關繫數為rs=-0.18(tt=-2.79,P=0.01);與腰臀比(0.91±0.05)的spearman秩相關繫數為rs=-0.28(tr=-4.44,P=0.00),而與人體質量指數(body mass index,BMI)[(26.85±3.10)ks/m2]無顯著相關性(rs=-0.10,tr=-1.45,P=0.15).脂聯素與胰島素牴抗相關指標關繫密切,包括空腹血糖[(5.48±1.72)mmol/L](rs=-0.13,tr=-2.00,P=0.05)、空腹胰島素[(11.52±5.34)mU/L](rs=-0.15,tr=-2.31,P=0.02)、穩態模式評估法的胰島素牴抗指數(HOMA-IR)(2.90±2.07)(rs=-0.17,tr=-2.63,P=0.01)及甘油三酯水平[(2.11±1.24)mmol/L](rs=-0.24,tr=-3.77,P=0.00).脂聯素與總膽固醇水平[(5.01±1.19)mmol/L](rs=-0.05,tr=-0.78,P=0.44)、高密度脂蛋白膽固醇(HDL-C)[(1.21±0.32)mmol/L](rs=0.06,tr=0.93,P=0.36)、收縮壓[(131.40±14.93)nun Hg,1 nun Hg=0.133 kPa](rs=-0.02,tr=-0.34,P=0.73)及舒張壓[(86.77±9.14)mm Hg](rs=-0.02,tr=-0.27,P=0.78)無顯著相關性.結論 MS患者血清脂聯素水平與腹部肥胖及胰島素牴抗相關指標呈負相關,而與血壓未見直接聯繫.
목적 탐토혈청지련소수평여대사종합정(metabolic syndrome,MS)각조분적상관성.방법 채용정군수궤추양적방법,추취상해시적량개성구,경조사화체검,사선출MS환자235례.통과대MS환자적지련소수평여MS각조분(요위、혈압、혈당、혈지)상관성분석급주성분회귀분석,초보탐토혈청지련소수평여MS각조분적관계.결과 남성지련소수평위(2.82±1.73)μg/ml저우녀성적(5.12±3.51)μg/ml,차이유통계학의의(Z=-5.25,P=0.00).지련소수평[(4.38±3.23)μg/ml]여복부비반상관,기여요위[(93.37±7.76)cm]적spearrnan질상관계수위rs=-0.18(tt=-2.79,P=0.01);여요둔비(0.91±0.05)적spearman질상관계수위rs=-0.28(tr=-4.44,P=0.00),이여인체질량지수(body mass index,BMI)[(26.85±3.10)ks/m2]무현저상관성(rs=-0.10,tr=-1.45,P=0.15).지련소여이도소저항상관지표관계밀절,포괄공복혈당[(5.48±1.72)mmol/L](rs=-0.13,tr=-2.00,P=0.05)、공복이도소[(11.52±5.34)mU/L](rs=-0.15,tr=-2.31,P=0.02)、은태모식평고법적이도소저항지수(HOMA-IR)(2.90±2.07)(rs=-0.17,tr=-2.63,P=0.01)급감유삼지수평[(2.11±1.24)mmol/L](rs=-0.24,tr=-3.77,P=0.00).지련소여총담고순수평[(5.01±1.19)mmol/L](rs=-0.05,tr=-0.78,P=0.44)、고밀도지단백담고순(HDL-C)[(1.21±0.32)mmol/L](rs=0.06,tr=0.93,P=0.36)、수축압[(131.40±14.93)nun Hg,1 nun Hg=0.133 kPa](rs=-0.02,tr=-0.34,P=0.73)급서장압[(86.77±9.14)mm Hg](rs=-0.02,tr=-0.27,P=0.78)무현저상관성.결론 MS환자혈청지련소수평여복부비반급이도소저항상관지표정부상관,이여혈압미견직접련계.
Objective To identify the relationship of adiponectin and the components of metabolic syndrome (MS). Methods Cluster random sampling was applied in two districts of Shanghai. Two communities were selected. After investigating and physical examination, 235 MS subjects were obtained. Correlation analysis and principle components regression analysis were used to analyze the relationship between adiponectin and components of MS (waist circumference, blood pressure, blood glucose and lipid). Results Adiponectin in male was (2.82±1.73 ) μg/ml, lower than in female [(5.12± 3.51 ) μg/ml] with statistical difference (Z =-5.25, P=0.00). Adiponectin levels [(4.38±3.23 ) μg/ml] correlated with abdominal obesity, including waist circumference [(93.37±7.76) cm] (rs=-0.18,tr =-2.79, P=0.01) and waist hip ratio (0.91±0.05 ) ( rs =-0.28,tr =-4.44, P = 0.00), but did not correlate significantly with body mass index (BMI) [(26.85±3.10) kg/m2] (rs=-0.10, tr =-1.45, P =0.15). Adiponectin correlated negatively with insulin resistance related indexes, including fasting glucose [ (5.48±1.72) mmol/L] ( rs =-0.13, tr =-2.00, P =0.05), fasting insulin [(11.52±5.34 ) mU/L] (rs=-0.15, tr=-2.31, P =0.02), homeostasis model assessment of insulin resistance (HOMA-IR) (2.90±2.07) (rs=-0.17,tr=-2.63,P=0.01) and trigliceride[(2.11±1.24) mmol/L] (rs=-0.24, ts=-3.77, P=0.00) . The correlations were not observed between adiponectin with total cholesterol [(5.01±1.19) mmol/L] (rs=-0.05, tr =-0.78, P=0.44), high density lipoprotein-cholesterol (HDL-C) [(1.21±0.32 ) mmol/L] (rs=0.06, tr=0.93, P=0.36), systolic blood pressure [(131.40±14.93) mm Hg,1 mm Hg =0.133 kPa] (ts=-0.02,tr=-0.34,P=0.73) and diastolic blood pressure[(86.77±9.14)mm Hg] (rs=-0.02,tr =-0.27 ,P=0.78). Conclusion Adiponectin should correlate negatively with abdominal obesity and insulin resistance, but not directly correlate with blood pressure in MS.
