中国中西医结合杂志(英文版)
中國中西醫結閤雜誌(英文版)
중국중서의결합잡지(영문판)
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2003年
1期
21-24
,共4页
杜金行%任在方%史载祥%黄力
杜金行%任在方%史載祥%黃力
두금행%임재방%사재상%황력
Xueshuantong%acute cerebral infarction%tissue type plasminogen%plasminogen inhibitor%D-D dimmer%antithrombin-Ⅲ%fibrinogen
Objective:To observe the effect of Xueshuantong injection(XST,血栓通注射液)with its ingredient as Notoginseng saponin, on acute cerebral infarction (ACI) and on blood coagulation and fibrinolysis, so as to comprehensively analyse the mechanism of XST. Methods: Fifty ACI patients were randomly divided into 2 groups, and XST group (30 patients) was treated with XST, and the control group (20 patients) given low molecular dextrose, as well as low molecular heparin calcium. The course of treatment for both groups was 15 days. The changes of effective rate, score of neurologic impairment, tissuetype plasminogen activator (tPA), inhibitor of plasminogen activator (PAI), D-D dimmer, antithrombinⅢ (AT-Ⅲ), and fibrinogen (Fbg) were all observed. Results: The total effective rate of XST group was 73.33%, that of the control group 65.00%. After the therapy, plasma level of tPA, ratio of tPA/PAI,and AT-Ⅲ content were increased obviously, while the plasma level of PAI and D-D dimmer were decreased significantly (all P<0.01). But there was only insignificant difference between the 2 groups (P>0.05). Conclusion: XST injection could be effective to ACI, the mechanism of which is probably related to improving the balance between plasminogen activator and its inhibitory factor, increasing the activity of fibrinolysin, inactivating thrombin, inhibiting platelet aggregation induced by thrombin, and decreasing blood coagulation.