CAJ | 학술논문

目的研究西安地区汉族人群中脂联素受体1(AdipoR1)的两个单核苷酸多态性(SNP)位点与2型糖尿病(T2DM)的关系.方法采用突变特异性扩增系统(ARMS)结合测序方法对西安地区100例T2DM患者(T2DM组)及84名正常对照者(NC组)AdipoR1基因的两个SNP位点进行分析.结果 (1)AdipoR1基因SNP-106A/G、SNP 5843A/G在DM组与NC组间基因型频率及等位基因频率差异无统计学意义.(2)AdipoR1基因5843 G/G型T2DM患者的诊断年龄明显早于A/A型+A/G型.结论在西安地区的汉族人群中,AdipoR1基因-106A/G、5843A/G的单个核苷酸多态性可能与T2DM的发病无关.携带5843 G/G基因型的T2DM患者发病年龄较早.
목적 연구서안지구한족인군중지련소수체1(AdipoR1)적량개단핵감산다태성(SNP)위점여2형당뇨병(T2DM)적관계.방법 채용돌변특이성확증계통(ARMS)결합측서방법대서안지구100례T2DM환자(T2DM조)급84명정상대조자(NC조)AdipoR1기인적량개SNP위점진행분석.결과 (1)AdipoR1기인SNP-106A/G、SNP 5843A/G재DM조여NC조간기인형빈솔급등위기인빈솔차이무통계학의의.(2)AdipoR1기인5843 G/G형T2DM환자적진단년령명현조우A/A형+A/G형.결론 재서안지구적한족인군중,AdipoR1기인-106A/G、5843A/G적단개핵감산다태성가능여T2DM적발병무관.휴대5843 G/G기인형적T2DM환자발병년령교조.
Objective To study the association of SNP of the AdipoR1 gene with T2DM in Xi’an population. Methods The amplification refractory mutation system(ARMS) analysis and gene sequencing were used to investigate the AdipoR1 gene polymorphism in 100 type 2 diabetics and 84 normal control subjects. Results (1) The genotype and allele frequencies of -106A/G, 5843A/G were not significantly different between type 2 diabetics and normal control subjects. (2) The diagnosis age of diabetics was significantly younger in AdipoR1 5843GG genotype group than in other genotype groups. Conclusions The data implicate that the AdipoR1 gene -106A/G and 5843A/G polymorphism may be not associated with pathogenesis of T2DM. AdipoR1 5843 GG genotype may be associated with the earlier diagnosis of T2DM