CAJ | 학술논문

目的:了解热休克蛋白40(heat shocking protein,Hsp 40)在卵巢上皮性癌中的表达并分析其与临床病理的相关性.方法:用免疫组织化学方法(immunohistochemistry,IHC)检测了45份卵巢上皮性癌、20份卵巢良性肿瘤、20份正常卵巢组织中Hsp 40蛋白的表达情况,将其表达结果与临床病理资料进行统计学分析.结果:Hsp 40蛋白在卵巢上皮性癌组织中表达的强度及阳性表达率明显高于卵巢良性肿瘤、正常卵巢组织,阳性表达率分别为62.2%、25.0%、20.0%,差异有高度统计学意义(P<0.01);卵巢上皮性癌组织中Hsp 40蛋白表达与其临床分期、组织学分级、有无远处转移及有无残余灶无明显相关性.Kaplan-Meier生存曲线及Log-rank分析显示Hsp 40蛋白表达阴性者的生存时间明显长于阳性表达者,差异有高度统计学意义(P<0.01).Cox模型显示残余病灶的大小单独进入Cox模型,而Hsp 40蛋白表达并不影响预后.结论:Hsp40蛋白可能在卵巢上皮性癌的发生、发展起重要作用.
목적:료해열휴극단백40(heat shocking protein,Hsp 40)재란소상피성암중적표체병분석기여림상병리적상관성.방법:용면역조직화학방법(immunohistochemistry,IHC)검측료45빈란소상피성암、20빈란소량성종류、20빈정상란소조직중Hsp 40단백적표체정황,장기표체결과여림상병리자료진행통계학분석.결과:Hsp 40단백재란소상피성암조직중표체적강도급양성표체솔명현고우란소량성종류、정상란소조직,양성표체솔분별위62.2%、25.0%、20.0%,차이유고도통계학의의(P<0.01);란소상피성암조직중Hsp 40단백표체여기림상분기、조직학분급、유무원처전이급유무잔여조무명현상관성.Kaplan-Meier생존곡선급Log-rank분석현시Hsp 40단백표체음성자적생존시간명현장우양성표체자,차이유고도통계학의의(P<0.01).Cox모형현시잔여병조적대소단독진입Cox모형,이Hsp 40단백표체병불영향예후.결론:Hsp40단백가능재란소상피성암적발생、발전기중요작용.
Objective:The expression of Hsp40 in epithelial ovarian cancer and its correlation with clinical pathology were investigated. Methods:The expression of Hsp40 was detected by immunohistochemistry in 45 cases of epithelial ovarian cancer and 20 cases of benign ovarian tumor and 20 cases of normal ovary. Sta-tistical analysis was done to correlate the expression of Hsp40 with pathological characteristics. Results:The expression of Hsp40 in epithelial ovarian cancer was significantly higher than benign ovarian tumor and nor-mal ovary, the positive rates were 62.2% ,25.0% and 20.0% respectively ( P <0.01 ). There was no signifi-cant correlation between the expression of Hsp40 and clinical stages, histological grades,with or without me-testasis, with or without residual tumor. Kaplan-Meier survival curves and Log - rank analysis showed that the survival time in Hsp40 expression negative patients was significantly longer than those positive expression patients( P <0.01 ). Cox analysis showed residual tumor size was the only one covariant factor, the expres-sion of Hsp40 was not significantly relevant to prognosis. Conclusions. Hsp40 may play an important role in the occurrence and development of epithelial ovarian cancer.