无机化学学报
無機化學學報
무궤화학학보
JOURNAL OF INORGANIC CHEMISTRY
2010年
9期
1699-1702
,共4页
张金超%李路伟%王立伟%张芳芳%秦新英%李小六
張金超%李路偉%王立偉%張芳芳%秦新英%李小六
장금초%리로위%왕립위%장방방%진신영%리소륙
抗肿瘤%钯(Ⅱ)配合物%单晶结构
抗腫瘤%鈀(Ⅱ)配閤物%單晶結構
항종류%파(Ⅱ)배합물%단정결구
antitumor%palladium(Ⅱ) complex%crystal structure
A novel palladium(Ⅱ) H) complex [Pd(Phen)(TsserNO)]·H2O (Phen=l,10-phenanthroline;TsserNO=4-toluenesulfonyl-L-serinate dianion) has been prepared and structurally characterized,the cytotoxicity in vitro has also been investigated by MTT and SRB assays.The complex crystallizes in the monoclinic system,space group P21 with cell parameters a=0.61864(14) nm,6=1.7689(4) nm,c=0.9902(2) nm,β=102.392(4)°,V=1.058 3(4) nm3 and Z=2.The complex had selectivity against HL-60,BGC-823,Bel-7402 and KB cells lines,its cytotoxicity is equal to that of cisplatin against BGC-823 and Bel-7402 cells lines,however it is less potent than cisplatin against HL-60 and KB cell lines.CCDC:756220.
