CAJ | 학술논문

目的探讨山西省贲门癌发病因素中遗传因素的作用.方法采用病例对照研究方法 ,对病例及对照的Ⅰ、Ⅱ、Ⅲ级亲属所有成员的姓名、性别、出生和死亡日期以及疾病诊断与治疗进行调查.用Falconer法和Li-Mentel-Gart法计算贲门癌的遗传度和分离比.结果 (1)病例组Ⅰ、Ⅱ、Ⅲ级亲属的贲门癌患病率分别是0.54%、0.04%、0.05%;病例组Ⅰ、Ⅱ、Ⅲ级亲属的上消化道癌患病率分别为2.50%、0.36%、0.13%.贲门癌与上消化道癌患病呈现Ⅰ>Ⅱ>Ⅲ级亲属的趋势,表现为家族聚集性,男女性均如此.(2)贲门癌先证者Ⅰ级亲属患贲门癌的遗传度为11.71%,其中女性为14.72%,男性为14.01%;贲门癌先证者Ⅰ级亲属患上消化道癌的遗传度为13.87%,其中女性为23.08%,男性为11.49%,均低于25%,属低遗传肿瘤.(3)病例组同胞中上消化道分离比为0.0452,其中男性为0.0441,女性为0.0507,均低于0.25,不符合单基因遗传方式,属多基因遗传方式.结论遗传因素是贲门癌的危险因素,但不是山西省贲门癌高发的主要危险因素.
목적 탐토산서성분문암발병인소중유전인소적작용.방법 채용병례대조연구방법 ,대병례급대조적Ⅰ、Ⅱ、Ⅲ급친속소유성원적성명、성별、출생화사망일기이급질병진단여치료진행조사.용Falconer법화Li-Mentel-Gart법계산분문암적유전도화분리비.결과 (1)병례조Ⅰ、Ⅱ、Ⅲ급친속적분문암환병솔분별시0.54%、0.04%、0.05%;병례조Ⅰ、Ⅱ、Ⅲ급친속적상소화도암환병솔분별위2.50%、0.36%、0.13%.분문암여상소화도암환병정현Ⅰ>Ⅱ>Ⅲ급친속적추세,표현위가족취집성,남녀성균여차.(2)분문암선증자Ⅰ급친속환분문암적유전도위11.71%,기중녀성위14.72%,남성위14.01%;분문암선증자Ⅰ급친속환상소화도암적유전도위13.87%,기중녀성위23.08%,남성위11.49%,균저우25%,속저유전종류.(3)병례조동포중상소화도분리비위0.0452,기중남성위0.0441,녀성위0.0507,균저우0.25,불부합단기인유전방식,속다기인유전방식.결론 유전인소시분문암적위험인소,단불시산서성분문암고발적주요위험인소.
Objective Studies on cardia-cancer caused by hereditary factors. Methods Case-control method was adopted,with information including name,sex,date of birth,date of death of all the Ⅰ,Ⅱ,Ⅲ relatives of the patients,diagnosis and the treatment collected. The hereditary probability of cardia cancer and the separation degree were calculated by Falconer and Li-Mentel-Gart. Results (1) Prevalence rates of cardia-cancer on relative Ⅰ,relative Ⅱ,relative Ⅲ of cardia-cancer patients appeared to be 0.54%,0.04%,and 0.05% respectively. Prevalence rates of upper-digestive-tract-cancer of relative Ⅰ,relative Ⅱ,relative Ⅲ of cardia-cancer patients showed as: 2.50%,0.36% and 0.13% respectively. Data showed that relative Ⅰ> relative Ⅱ> relative Ⅲ and family cluster existed in both males and females. (2) Cardia-cancer hereditary probability of the relative Ⅰ cardia-cancer probands was 11.71%,with males as 14.01% and females as 14.72%. The upper-digestive-tract-cancer hereditary probability of the relative Ⅰ cardia-cancer probands was 13.87%,with males as 11.49% and females as 23.08%,both below 25%,indicating this was a low hereditary cancer. (3) The upper-digestive-tract-cancer separation of the blood compatriots of cardia-cancer patients was 0.0452,with males as 0.0441 and females as 0.0507,both below 0.25,indicating the nature of a multi-gene but not single-gene hereditary way. Conclusion Hereditary factor is recognized as one of the high risk cardia cancer,but not the most risky factor causing the high morbidity of cardia cancer in Shanxi province.