CAJ | 학술논문

目的评估一种以电化学为原理、利用离子渗透技术的无创设备(EZSCAN)筛查糖尿病(DM)、糖耐量受损(IGT)和代谢综合征(MS)的效能.方法既往无明确血糖异常者 166例,常规体检,分别应用经典方法空腹血糖(FPG)、糖化血红蛋白(HbA1c)、糖耐量试验(OGTT)和EZSCAN检测个体血糖状态.运用方差分析(GLM)、SNK分析,并运用logistic回归分析、ROC分析评价诊断价值.结果经典方法和EZSCAN检测出DM 4例;IGT 26例;FPG正常(NGT)合并MS 25例;FPG正常且无MS 111例.经典方法检测FPG处于临界水平(7.0 mmol/L)时,检测DM的敏感性低(0%).而EZSCAN检测的敏感性,对DM为50%,对IGT为77%,对MS为64%.结论在本研究组中,用FPG检测DM敏感性较低.而使用EZSCAN技术检测,不仅对DM和IGT都具有良好的敏感性,而且对于识别NGT合并MS也具有良好的敏感性.EZSCAN新技术可能是IGT、DM 及MS早期筛查的有效方法.
목적 평고일충이전화학위원리、이용리자삼투기술적무창설비(EZSCAN)사사당뇨병(DM)、당내량수손(IGT)화대사종합정(MS)적효능.방법 기왕무명학혈당이상자 166례,상규체검,분별응용경전방법 공복혈당(FPG)、당화혈홍단백(HbA1c)、당내량시험(OGTT)화EZSCAN검측개체혈당상태.운용방차분석(GLM)、SNK분석,병운용logistic회귀분석、ROC분석평개진단개치.결과 경전방법 화EZSCAN검측출DM 4례;IGT 26례;FPG정상(NGT)합병MS 25례;FPG정상차무MS 111례.경전방법 검측FPG처우림계수평(7.0 mmol/L)시,검측DM적민감성저(0%).이EZSCAN검측적민감성,대DM위50%,대IGT위77%,대MS위64%.결론 재본연구조중,용FPG검측DM민감성교저.이사용EZSCAN기술검측,불부대DM화IGT도구유량호적민감성,이차대우식별NGT합병MS야구유량호적민감성.EZSCAN신기술가능시IGT、DM 급MS조기사사적유효방법.
Objective To assess the efficiency of an iontophoresis-based screening method (EZSCAN) in the detection of impaired glucose tolerance (IGT),diabetes mellitus (DM) and metabolic syndrome (MS).Methods A total of 166 subjects without medical history of dysglycaemia underwent fasting plasma glucose (FPG) and HbA1c measurement and oral glucose tolerance test (OGTT) by using traditional or EZSCAN method.Variance analysis (GLM),SNK analysis,logistic regression analysis,and ROC analysis were used to evaluate the diagnostic value of those screening techniques.Results DM,IGT,normal glucose tolerance (NGT) +MS,and NGT were found in 4,26,25 or 111 participants,respectively.For traditional test,FPG of 7.0 mmol/L showed a lower sensitivity to detect DM (0%).The sensitivity of EZSCAN to detect DM,IGT or MS was 50%,77% and 64%,respectively.Conclusions FPG may have lower sensitivity to detect DM,although EZSCAN could show higher sensitivity to detect IGT,DM,and MS.