中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2008年
9期
53-55
,共3页
李运泉%陈国桢%王慧深%覃有振%李淑娟%李格丽
李運泉%陳國楨%王慧深%覃有振%李淑娟%李格麗
리운천%진국정%왕혜심%담유진%리숙연%리격려
心肌病%扩张型%小儿%静脉用丙种球蛋白%预后%生存分析
心肌病%擴張型%小兒%靜脈用丙種毬蛋白%預後%生存分析
심기병%확장형%소인%정맥용병충구단백%예후%생존분석
Cardiomyopathy,dilated%Children%IVlG%Prognosis%Analysis of survival
目的 探讨小儿扩张型心肌病(DCM)的预后和静脉用丙种球蛋白(IVIG)治疗小儿DCM的疗效.方法 对34例小儿 DCM患者的临床资料和随访结果进行分析,按治疗方法分成常规应用洋地黄、利尿剂及血管紧张素转换酶抑制剂(ACEI)治疗的常规治疗组和在常规治疗基础上加用大剂量IVIG治疗的IVIG治疗组.采用SPSS13.0软件包寿命表法和Kaplan-Meier法进行生存分析和两种治疗方法疗效比较分析.P＜0.05为差异有统计学意义.结果 常规治疗组16例:男10例,女6例,平均7.8岁(7月～14岁).IVIG治疗组18例:男11例,女7例,平均7.5岁(9月～12岁).本组DCM患者死亡8例(23.5%),确诊并治疗后5年生存率为48%,IVIG治疗组的5年生存率为64%.生存分析显示IVIG治疗组较对照组能延长患者生存时间和减少心用血管活性药物及住院次数(P＜0.05).结论 小儿DCM预后不佳,应用大剂量IVIC治疗有助于改善其预后.
目的 探討小兒擴張型心肌病(DCM)的預後和靜脈用丙種毬蛋白(IVIG)治療小兒DCM的療效.方法 對34例小兒 DCM患者的臨床資料和隨訪結果進行分析,按治療方法分成常規應用洋地黃、利尿劑及血管緊張素轉換酶抑製劑(ACEI)治療的常規治療組和在常規治療基礎上加用大劑量IVIG治療的IVIG治療組.採用SPSS13.0軟件包壽命錶法和Kaplan-Meier法進行生存分析和兩種治療方法療效比較分析.P＜0.05為差異有統計學意義.結果 常規治療組16例:男10例,女6例,平均7.8歲(7月～14歲).IVIG治療組18例:男11例,女7例,平均7.5歲(9月～12歲).本組DCM患者死亡8例(23.5%),確診併治療後5年生存率為48%,IVIG治療組的5年生存率為64%.生存分析顯示IVIG治療組較對照組能延長患者生存時間和減少心用血管活性藥物及住院次數(P＜0.05).結論 小兒DCM預後不佳,應用大劑量IVIC治療有助于改善其預後.
목적 탐토소인확장형심기병(DCM)적예후화정맥용병충구단백(IVIG)치료소인DCM적료효.방법 대34례소인 DCM환자적림상자료화수방결과진행분석,안치료방법분성상규응용양지황、이뇨제급혈관긴장소전환매억제제(ACEI)치료적상규치료조화재상규치료기출상가용대제량IVIG치료적IVIG치료조.채용SPSS13.0연건포수명표법화Kaplan-Meier법진행생존분석화량충치료방법료효비교분석.P＜0.05위차이유통계학의의.결과 상규치료조16례:남10례,녀6례,평균7.8세(7월～14세).IVIG치료조18례:남11례,녀7례,평균7.5세(9월～12세).본조DCM환자사망8례(23.5%),학진병치료후5년생존솔위48%,IVIG치료조적5년생존솔위64%.생존분석현시IVIG치료조교대조조능연장환자생존시간화감소심용혈관활성약물급주원차수(P＜0.05).결론 소인DCM예후불가,응용대제량IVIC치료유조우개선기예후.
Objective To assess the prognosis of dilated cardiomyopathy(DCM) in children and to evaluate the effect of IVIG on pediatric patients with DCM.Methods34 patients were enrolled,and they were divided into conventional treatment group and IVIG group (conventional treatment plus large dose IVIG) .Statistical analysis were carried out in SPSS13.0 software.Life table and Kaplan-Meier analysis were used to analyze the survival and the comparison of treatment effeet between two groups.P ＜ O.05 is statistically significant.Results Conventional treatment group had 16 cases (male 10 and female 6) aged from 7 month to 14 years old (median 7.8 years) ,and IVIG group had 18 eases(male 11 and female 7) aged from 9 month to 12 years old (median 7.5years) .From the enrolled patients were diagnosed and treatment,8 patients(23.5%) died and five-year survival rates was 48%,while five-year survival rates was 64% in IVIG group.Analysis of survival display survival time of patients in IVIG group was longer than that of patients in conventional treatment group,both application of vasoactive agents and hospitalization times were fewer in IVIG group than those of patients in conventional treatment group (P ＜ 0.05).ConclusionThe prognosis of DCM in pediatric patients is not good.Application of large dose IVIG is beneficial to the patients with DCM in children.
