肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2008年
3期
179-181
,共3页
邓丽云%郭晋铎%贺萍%赵丽%赵嘉训
鄧麗雲%郭晉鐸%賀萍%趙麗%趙嘉訓
산려운%곽진탁%하평%조려%조가훈
二异丙酚%诱发电位,听觉
二異丙酚%誘髮電位,聽覺
이이병분%유발전위,은각
Propofol%Evoked potentials,auditory
目的 探讨二异丙酚靶控输注(TCI)血药浓度与听觉诱发电位指数(AAI)的相关性.方法 选择ASA Ⅰ～Ⅱ级腹部择期手术的肿瘤患者10例.桡动脉置管以采集血样.二异丙酚TCI系统使用法国Base Primea公司Orchestra输注泵,内嵌Schnider药代学参数,靶质量浓度在麻醉诱导设定为3mg/L,气管插管后调为1.7～2.5mg/L,复合吸入0.5MAC的异氟醚.术中无创麻醉深度监测仪监测听觉深度AAI值.分别于二异丙酚诱导即刻(T0)、诱导后1、3、5、10、15、30、60、90min(T1-8)、停止输注后10、20 min(T9-10)采桡动脉血5 ml,用荧光光度仪检测二异丙酚的血药浓度.结果 实测质量浓度显著低于靶质量浓度(P＜0.05),实测质量浓度与靶质量浓度间呈不平行关系,实测质量浓度随时间的延长有下降的趋势.AAI值与实测质量浓度呈显著负相关(r=-0.818,P＜0.01).结论 应用Schnider参数进行二异丙酚TCI实测质量浓度与靶质量浓度间呈不平行关系,实测质量浓度随时间的延长有下降的趋势;AAI值与二异丙酚血药质量浓度之间呈显著负相关,可间接反映二异丙酚血药质量浓度.
目的 探討二異丙酚靶控輸註(TCI)血藥濃度與聽覺誘髮電位指數(AAI)的相關性.方法 選擇ASA Ⅰ～Ⅱ級腹部擇期手術的腫瘤患者10例.橈動脈置管以採集血樣.二異丙酚TCI繫統使用法國Base Primea公司Orchestra輸註泵,內嵌Schnider藥代學參數,靶質量濃度在痳醉誘導設定為3mg/L,氣管插管後調為1.7～2.5mg/L,複閤吸入0.5MAC的異氟醚.術中無創痳醉深度鑑測儀鑑測聽覺深度AAI值.分彆于二異丙酚誘導即刻(T0)、誘導後1、3、5、10、15、30、60、90min(T1-8)、停止輸註後10、20 min(T9-10)採橈動脈血5 ml,用熒光光度儀檢測二異丙酚的血藥濃度.結果 實測質量濃度顯著低于靶質量濃度(P＜0.05),實測質量濃度與靶質量濃度間呈不平行關繫,實測質量濃度隨時間的延長有下降的趨勢.AAI值與實測質量濃度呈顯著負相關(r=-0.818,P＜0.01).結論 應用Schnider參數進行二異丙酚TCI實測質量濃度與靶質量濃度間呈不平行關繫,實測質量濃度隨時間的延長有下降的趨勢;AAI值與二異丙酚血藥質量濃度之間呈顯著負相關,可間接反映二異丙酚血藥質量濃度.
목적 탐토이이병분파공수주(TCI)혈약농도여은각유발전위지수(AAI)적상관성.방법 선택ASA Ⅰ～Ⅱ급복부택기수술적종류환자10례.뇨동맥치관이채집혈양.이이병분TCI계통사용법국Base Primea공사Orchestra수주빙,내감Schnider약대학삼수,파질량농도재마취유도설정위3mg/L,기관삽관후조위1.7～2.5mg/L,복합흡입0.5MAC적이불미.술중무창마취심도감측의감측은각심도AAI치.분별우이이병분유도즉각(T0)、유도후1、3、5、10、15、30、60、90min(T1-8)、정지수주후10、20 min(T9-10)채뇨동맥혈5 ml,용형광광도의검측이이병분적혈약농도.결과 실측질량농도현저저우파질량농도(P＜0.05),실측질량농도여파질량농도간정불평행관계,실측질량농도수시간적연장유하강적추세.AAI치여실측질량농도정현저부상관(r=-0.818,P＜0.01).결론 응용Schnider삼수진행이이병분TCI실측질량농도여파질량농도간정불평행관계,실측질량농도수시간적연장유하강적추세;AAI치여이이병분혈약질량농도지간정현저부상관,가간접반영이이병분혈약질량농도.
Objective To assess the relationship between auditory evoked potential (AAI) index and plasma concentration of propofol administered by target-controlled infusion (TCI) in Chinese.Methods Ten ASA Ⅰ～Ⅱ tumor patients (5 males,5 females) scheduled for elective abdominal surgery under general anesthesia was enrolled in this study.Age ranged from 34 to 61 years,body weight from 52 to 79 kg and height from 155 to 178 cm.Radial artery was cannulated for blood sampling.The patients were premeditated with intravenous injection Midazolam 0.06 mg/L.Anesthesia was induced by fentanyl 2μg/kg,vecuronium 0.1 mg/kg and TCI of propofol which the target plasm concentration was set at 3 mg/L.After intubation,the target plasma concentration of propofol was adjusted at 1.7～2.5 mg/L.Vecuronium was continuous infusions at 2～3mg/h.Anesthesia was maintained with fentanyl-TCI of propofol-vecuronium and inhalation of 0.5 MAC isoflurane.The TCI system was composed of Base Primea company orchestra infusion pump using,the schnider pharmacokinetics model.ECG,Bp,HR,PETCO2,SpO2 and TETISO were monitored during anesthesia.Danmeter company A-line depth of anesthesia monitor recorded AAI index.Blood samples were taken at induction of anesthesia (To baseline),1,3,5,10,15,30,60 min (T1-7) and after cessation of infusion 10 and 20 min (T9-10).Plasma propofol concentration were determinated by fluorescence photometry.Results Compared with target concentrations,the measured concentrations of propofol were significantly lower during TCI(P＜0.05).There was negative correlation between AAI and plasma propofol concentrations(r=-0.818,P＜0.01).Conclusion On base of the Schnider pharmacokinetics model,the target propofol concentrations are not paralleled to plasma propofol concentrations which is descending with time prolongation.From negative correlation between AAI index and plasma propofol concentrations,AAI index will reflect indirectly plasma propofol concentrations.
