国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2011年
4期
334-336
,共3页
间充质于细胞%toll样受体%急性肺损伤%机制
間充質于細胞%toll樣受體%急性肺損傷%機製
간충질우세포%toll양수체%급성폐손상%궤제
Mesenchymal stem cells%Toll-like receptors%Acute lung injury%Mechanism
急性肺损伤(acute lung injury,ALI)是由感染、氧中毒、机械刺激等多种原因引起的肺部弥漫性损害,病死率高,目前尚无特效的治疗方法.研究表明间充质干细胞(mesenchymal stem cells,MSC)可通过toll样受体的调节向肺损伤部位定向移行,并通过分泌可溶性细胞因子改变组织微环境,促进肺损伤的修复.随着对MSC在ALI中的作用及机制的深入研究,将为ALI找到新的治疗策略.
急性肺損傷(acute lung injury,ALI)是由感染、氧中毒、機械刺激等多種原因引起的肺部瀰漫性損害,病死率高,目前尚無特效的治療方法.研究錶明間充質榦細胞(mesenchymal stem cells,MSC)可通過toll樣受體的調節嚮肺損傷部位定嚮移行,併通過分泌可溶性細胞因子改變組織微環境,促進肺損傷的脩複.隨著對MSC在ALI中的作用及機製的深入研究,將為ALI找到新的治療策略.
급성폐손상(acute lung injury,ALI)시유감염、양중독、궤계자격등다충원인인기적폐부미만성손해,병사솔고,목전상무특효적치료방법.연구표명간충질간세포(mesenchymal stem cells,MSC)가통과toll양수체적조절향폐손상부위정향이행,병통과분비가용성세포인자개변조직미배경,촉진폐손상적수복.수착대MSC재ALI중적작용급궤제적심입연구,장위ALI조도신적치료책략.
Acute lung injury (ALI) is a diffuse lung damage with high mortality, initiated by infection, oxygentoxicity, mechanical stimulation and so on. Currenty there are no specific treatment strategies. Recently, numerous studies indicate that mesenchymal stem cells (MSC) are able to migrate to the sites of lung injury and affect the tissue microenvironment via secretion of soluble factors by the modulation of toll-like receptors ( TLR) , which contributes to lung repair. With the further study of effect and mechanism of MSCs in ALI, innovative therapies for ALI will be found.
