CAJ | 학술논문

TC-1是由TC-1基因编码的核蛋白,能够调控细胞分裂周期,参与基因转录和翻译的调节,与正常细胞和肿瘤细胞的增殖有关.TC-1参与Wnt信号转导通路的激活,可以促进多种癌基因表达上调,与甲状腺癌、胃癌、乳腺癌等肿瘤的恶性转化和进展有关.TC-1作为一种潜在的肿瘤相关蛋白,将有望用于肿瘤的基础理论研究和基因靶向治疗.
TC-1시유TC-1기인편마적핵단백,능구조공세포분렬주기,삼여기인전록화번역적조절,여정상세포화종류세포적증식유관.TC-1삼여Wnt신호전도통로적격활,가이촉진다충암기인표체상조,여갑상선암、위암、유선암등종류적악성전화화진전유관.TC-1작위일충잠재적종류상관단백,장유망용우종류적기출이론연구화기인파향치료.
thyroid cancer(TC-1 ),a nuclear protein coded by TC-1,regulates the cell cycle,participates transcription and translation,and is correlated with the proliferation of normal and cancer cells.TC-1 participates in the Wnt/beta-catenin signaling pathway which can promote the up-regulation of proto-oncogene.Hence it plays an important role in the malignant transformation and development of the tumors,such as thyroid cancer,gastric cancer and breast cancer.Therefore,as a potential tumor-associated protein,it's likely to be used for fundamental research and gene targeting therapy.