CAJ | 학술논문

目的研究改性壳聚糖防粘连膜用于预防开腹手术后肠粘连的临床效果.方法复旦大学附属中山医院普外科2006年1-12月间的240例腹部外科手术病例,随机分成两组,试验组关闭腹部切口前在手术创面和切口下放置改性壳聚糖防粘连膜,对照组则不放置.观察术后胃肠道功能恢复情况,术后腹痛程度和持续时间,手术后并发症发生率,并随访术后1年内腹痛和粘连性肠梗阻的发生率.结果试验组术后腹痛症状较对照组明显减轻,术后肠道功能恢复和进食时间明显早于对照组,术后1年内粘连性肠梗阻发生率明显下降.术后并发症发生率两组间无明显统计学差异.结论改性壳聚糖防粘连膜的使用有助于改善腹部外科术后腹腔粘连,减少粘连性肠梗阻的发生.
목적 연구개성각취당방점련막용우예방개복수술후장점련적림상효과.방법 복단대학부속중산의원보외과2006년1-12월간적240례복부외과수술병례,수궤분성량조,시험조관폐복부절구전재수술창면화절구하방치개성각취당방점련막,대조조칙불방치.관찰술후위장도공능회복정황,술후복통정도화지속시간,수술후병발증발생솔,병수방술후1년내복통화점련성장경조적발생솔.결과 시험조술후복통증상교대조조명현감경,술후장도공능회복화진식시간명현조우대조조,술후1년내점련성장경조발생솔명현하강.술후병발증발생솔량조간무명현통계학차이.결론 개성각취당방점련막적사용유조우개선복부외과술후복강점련,감소점련성장경조적발생.
Objective To evaluate a chemically-modified chitosan anti-adhesion film in the prevention of intestinal adhesion after abdominal surgery.Method In this study 240 patients at the Department of Surgery, Fudan University Zhongshan Hospital undergoing abdominal surgery from Jan 2006 to Dec 2006 were randomly divided into two groups.In the research group, chemically-modified chitosan antiadhesion film was put both at the area of operation and under the incision before closing the abdomen.The recovery procedures were recorded including the recovery of gut movement, the degree and the lasting time of abdominal pain, complication after surgery, the abdominal pain and ileus within 1 year.Result Postoperative incision pain was less significant in research group.The gut function recovered quicker and dietary began earlier.The ratio of early ileus after the surgery decreased significantly.The abdominal adhesion symptom in 1 year after surgery ameliorated significantly.There was no significant difference in other postoperative complications in the two groups.Conclusion The use of chemicallymodified chitosan anti-adhesion film helps to prevent the intestinal adhesion after the abdominal surgery.