CAJ | 학술논문

Survivin是IAP家族中最年轻的成员,在几乎所有的肿瘤细胞中高表达,而在大多数的正常细胞中没有检测到.由于其表达的选择性引起人们的兴趣,认为是肿瘤细胞的分子标志之一.同样Survivin已经在多数的白血病细胞株和白血病标本中被检测到,并展示了其表达与白血病的关系.同其他肿瘤细胞一样,Survivin在白血病的发病中起到重要作用,同时Survivin的检测可以提供有用的预后信息.现就Survivin的研究进展以及与白血病的关系做简要综述.
Survivin시IAP가족중최년경적성원,재궤호소유적종류세포중고표체,이재대다수적정상세포중몰유검측도.유우기표체적선택성인기인문적흥취,인위시종류세포적분자표지지일.동양Survivin이경재다수적백혈병세포주화백혈병표본중피검측도,병전시료기표체여백혈병적관계.동기타종류세포일양,Survivin재백혈병적발병중기도중요작용,동시Survivin적검측가이제공유용적예후신식.현취Survivin적연구진전이급여백혈병적관계주간요종술.
Survivin is the most recent member of the IAP family, which shows a higher expression in almost all tumor cells, but not detected in most normal cells. Our attention is drawn by survivin due to its selective expression, which was taken as one molecule sign of tumor cells. Accordingly, survivin is examined in most leukemia cell line and leukemia specimen, whose expression also showed the association with leukemia. As in other tumor cells, survivin also plays an important role in the leukemogenesis. Meanwhile the detection of survivin can provide an useful prognosis information. This article is a brief overview of the development of survivin and its relationship with leukemia.