中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2010年
4期
305-308
,共4页
朱麒钱%楼大钧%斯徐伟%官莉莉%尤巧英%俞钟明%张爱珍%李铎
硃麒錢%樓大鈞%斯徐偉%官莉莉%尤巧英%俞鐘明%張愛珍%李鐸
주기전%루대균%사서위%관리리%우교영%유종명%장애진%리탁
糖尿病,2型%胰岛素抗药性%脂肪酸类,不饱和%脂肪肝,非酒精性
糖尿病,2型%胰島素抗藥性%脂肪痠類,不飽和%脂肪肝,非酒精性
당뇨병,2형%이도소항약성%지방산류,불포화%지방간,비주정성
Diabetes mellitus,type 2%Insulin resistance%Fatty acid,unsaturated%Fatty liver,non-alcoholic
目的 研究2型糖尿病伴非酒精性脂肪肝(NAFLD)患者胰岛素抵抗与ω-3多不饱和脂肪酸(ω-3PUFA)的关系.方法 2型糖尿病伴NAFLD患者51例、单纯2型糖尿病患者50例、单纯NAFLD患者45例、健康对照组42例为研究对象.用高效气相色谱法测定所有研究对象的血清ω-3PUFA,HOMA胰岛素抵抗指数(HOMA-IR)评价胰岛素抵抗,同时检测所有对象的ALT、AST、γ-谷氨酰转移酶(GGT)、TC、TG、LDL-C、HDL-C等指标.结果 2型糖尿病伴NAFLD组的HOMA-IR(4.90±2.54)高于单纯2型糖尿病组(2.38±1.23)、单纯NAFLD组(2.20±1.15)及对照组(1.13±0.42),P值均<0.05;2型糖尿病伴NAFLD组的ALT、AST、GGT、TC、TG和LDL-C高于单纯2型糖尿病组、单纯NAFLD组、对照组(P值均<0.05);2型糖尿病伴NAFLD组的ω-3PUFA总量[(5.68±2.02)%]显著低于单纯2型糖尿病组[(7.17±2.38)%]、单纯NAFLD组[(6.97±2.32)%]及对照组[(10.08±2.76)%],P值均<0.05;相关性分析显示,ω-3PUFA与HOMA-IR及TC、TG、LDL-C均呈负相关(r值分别为-0.491及-0.376、-0.462、-0.408,P值均<0.05).结论 2型糖尿病伴NAFLD患者血清ω-3PUFA总量显著下降,与胰岛素抵抗呈负相关,可能在疾病的发生发展中具有重要作用.
目的 研究2型糖尿病伴非酒精性脂肪肝(NAFLD)患者胰島素牴抗與ω-3多不飽和脂肪痠(ω-3PUFA)的關繫.方法 2型糖尿病伴NAFLD患者51例、單純2型糖尿病患者50例、單純NAFLD患者45例、健康對照組42例為研究對象.用高效氣相色譜法測定所有研究對象的血清ω-3PUFA,HOMA胰島素牴抗指數(HOMA-IR)評價胰島素牴抗,同時檢測所有對象的ALT、AST、γ-穀氨酰轉移酶(GGT)、TC、TG、LDL-C、HDL-C等指標.結果 2型糖尿病伴NAFLD組的HOMA-IR(4.90±2.54)高于單純2型糖尿病組(2.38±1.23)、單純NAFLD組(2.20±1.15)及對照組(1.13±0.42),P值均<0.05;2型糖尿病伴NAFLD組的ALT、AST、GGT、TC、TG和LDL-C高于單純2型糖尿病組、單純NAFLD組、對照組(P值均<0.05);2型糖尿病伴NAFLD組的ω-3PUFA總量[(5.68±2.02)%]顯著低于單純2型糖尿病組[(7.17±2.38)%]、單純NAFLD組[(6.97±2.32)%]及對照組[(10.08±2.76)%],P值均<0.05;相關性分析顯示,ω-3PUFA與HOMA-IR及TC、TG、LDL-C均呈負相關(r值分彆為-0.491及-0.376、-0.462、-0.408,P值均<0.05).結論 2型糖尿病伴NAFLD患者血清ω-3PUFA總量顯著下降,與胰島素牴抗呈負相關,可能在疾病的髮生髮展中具有重要作用.
목적 연구2형당뇨병반비주정성지방간(NAFLD)환자이도소저항여ω-3다불포화지방산(ω-3PUFA)적관계.방법 2형당뇨병반NAFLD환자51례、단순2형당뇨병환자50례、단순NAFLD환자45례、건강대조조42례위연구대상.용고효기상색보법측정소유연구대상적혈청ω-3PUFA,HOMA이도소저항지수(HOMA-IR)평개이도소저항,동시검측소유대상적ALT、AST、γ-곡안선전이매(GGT)、TC、TG、LDL-C、HDL-C등지표.결과 2형당뇨병반NAFLD조적HOMA-IR(4.90±2.54)고우단순2형당뇨병조(2.38±1.23)、단순NAFLD조(2.20±1.15)급대조조(1.13±0.42),P치균<0.05;2형당뇨병반NAFLD조적ALT、AST、GGT、TC、TG화LDL-C고우단순2형당뇨병조、단순NAFLD조、대조조(P치균<0.05);2형당뇨병반NAFLD조적ω-3PUFA총량[(5.68±2.02)%]현저저우단순2형당뇨병조[(7.17±2.38)%]、단순NAFLD조[(6.97±2.32)%]급대조조[(10.08±2.76)%],P치균<0.05;상관성분석현시,ω-3PUFA여HOMA-IR급TC、TG、LDL-C균정부상관(r치분별위-0.491급-0.376、-0.462、-0.408,P치균<0.05).결론 2형당뇨병반NAFLD환자혈청ω-3PUFA총량현저하강,여이도소저항정부상관,가능재질병적발생발전중구유중요작용.
Objective To investigate the relationship between serum omega-3 polyunsaturated fatty acid (ω-3PUFA) and insulin resistance(IR) in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). Methods This trial involved 51 patients of type 2 diabetes mellitus with NAFLD (G4 group), 50 patients of type 2 diabetes alone(G3 group), 45 patients of NAFLD alone (G2 group) and 42 healthy control subjects (G1 group). Serum ω-3PUFA profile was analyzed with capillary gas chromatography. Insulin resistance was assessed by homeostasis model assessment (HOMA-IR). ALT, AST, γ-glutamyltransferase(GGT) and serum lipids were measured. Results The levels of HOMA-IR were higher in G4 group than those in G3, G2 and G1 group(4. 90 ± 2. 54 vs 2. 38 ± 1.23, 2. 20 ± 1.15, 1.13± 0.42;P<0.05). The level of ALT, AST, GGT, TC, TG, LDL-C were higher in G4 group than those in G3, G2 and G1 group(P < 0. 05). The level of ω-3PUFA was signifieantly lower in G4 group than those in G3, G2 and G1 group(5.68 ±2.02 vs 7. 17 ±2. 38, 6.97±2.32, 10.08±2.76;P <0.05). ω-3PUFA cocentration was negatively correlated with HOMA-IR, TC, TG and LDL-C (r = -0.491, -0. 376, - 0. 462, - 0. 408, P < 0. 05). Conclusions Serum ω-3 PUFA is significantly decreased in patients with type 2 diabetes mellitus and NAFLD. Serum ω-3PUFA is negatively correlated with insulin resistance. ω-3PUEA plays a very important role in the development of diabetes mellitus and NAFLD.
