中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
19期
12-14
,共3页
随机对照试验%头孢唑林%细菌感染%头孢西酮
隨機對照試驗%頭孢唑林%細菌感染%頭孢西酮
수궤대조시험%두포서림%세균감염%두포서동
Randomized controlled trials%Cefazolin%Bacterial infections%Cefazedone
目的 评价头孢西酮钠治疗急性呼吸道细菌感染的临床疗效和安全性.方法 采用随机、单盲、平行对照设计,试验组35例应用头孢西酮钠,每次2 g,每日2次静脉滴注.对照组37例应用头孢唑林钠,每次2 g,每日2次静脉滴注.疗程均为5～14d.共入选病例72例,剔除1例,脱落5例,可评价66例,试验组34例,对照组32例,安全性评价71例.结果 试验组和对照组有效率分别为91.18%(31/34)和78.12%(25/32),细菌清除率分别为80.00%(20/25)、84.00%(21/25),不良反应发生率分别为22.86%(8/35)、16.67%(6/36),两组比较差异均无统计学意义(P>0.05).结论 头孢西酮钠治疗急性呼吸道细菌感染安全、有效.
目的 評價頭孢西酮鈉治療急性呼吸道細菌感染的臨床療效和安全性.方法 採用隨機、單盲、平行對照設計,試驗組35例應用頭孢西酮鈉,每次2 g,每日2次靜脈滴註.對照組37例應用頭孢唑林鈉,每次2 g,每日2次靜脈滴註.療程均為5～14d.共入選病例72例,剔除1例,脫落5例,可評價66例,試驗組34例,對照組32例,安全性評價71例.結果 試驗組和對照組有效率分彆為91.18%(31/34)和78.12%(25/32),細菌清除率分彆為80.00%(20/25)、84.00%(21/25),不良反應髮生率分彆為22.86%(8/35)、16.67%(6/36),兩組比較差異均無統計學意義(P>0.05).結論 頭孢西酮鈉治療急性呼吸道細菌感染安全、有效.
목적 평개두포서동납치료급성호흡도세균감염적림상료효화안전성.방법 채용수궤、단맹、평행대조설계,시험조35례응용두포서동납,매차2 g,매일2차정맥적주.대조조37례응용두포서림납,매차2 g,매일2차정맥적주.료정균위5～14d.공입선병례72례,척제1례,탈락5례,가평개66례,시험조34례,대조조32례,안전성평개71례.결과 시험조화대조조유효솔분별위91.18%(31/34)화78.12%(25/32),세균청제솔분별위80.00%(20/25)、84.00%(21/25),불량반응발생솔분별위22.86%(8/35)、16.67%(6/36),량조비교차이균무통계학의의(P>0.05).결론 두포서동납치료급성호흡도세균감염안전、유효.
Objective To evaluate the clinical efficacy and safety of the cefazedone sodium in treatment of respiratory tract bacterial infections. Methods Single-blind randomized control trial was performed to evaluate the efficacy and safety of cefazedone sodium in treatment of respiratory tract bacterial infections, and cefazolin sodium as the controlled one. Patients in trial group (using cefazedone sodium, 35 patients) and control group (using cefazolin sodium, 37 patients) were all intravenously administered at the same doses of 2 g, every 12 hours for 5 to 14 days. A total of 72 patients were enrolled in the studies, 34 in trial group and 32 in control group, with 1 excluded and 5 withdrawn. Safety assessment was conducted in 71 patients. Results In trial group and control group, the total cure rates for respiratory tract infections were 91.18% (31/34) and 78.12%(25/32), and the general bacterial eradication rates were 80.00% (20/25) and 84.00% (21/25). The adverse drug reaction rates were 22.86 %(8/35) and 16.67% (6/36),there was no significant difference (P > 0.05 ). Conclusion Cefazedone sodium is a safe and effective antibiotic in the treatment of acute respiratory tract bacterial infections.
