CAJ | 학술논문

趋化因子是能够激发白细胞趋化性的小分子分泌性蛋白质,是可受化学诱导物及细胞因子调节、并能刺激细胞趋化运动的一类细胞因子.趋化因子将循环中的淋巴细胞募集到组织损伤或炎症反应部位.早期对趋化因子的研究是基于其在炎症中的功能.最近发现趋化因子及其受体和机体内单核细胞的迁移,适应性免疫应答以及多种疾病的发病机理相关.趋化因子受体作为炎症和免疫应答的调控分子而成为多种药物的靶向分子.临床上已经开始利用趋化因子的拈抗剂治疗炎症疾病,本篇旨在阐述趋化因子及其受体在炎症疾病中的作用以及这些趋化因子在临床上的应用.
추화인자시능구격발백세포추화성적소분자분비성단백질,시가수화학유도물급세포인자조절、병능자격세포추화운동적일류세포인자.추화인자장순배중적림파세포모집도조직손상혹염증반응부위.조기대추화인자적연구시기우기재염증중적공능.최근발현추화인자급기수체화궤체내단핵세포적천이,괄응성면역응답이급다충질병적발병궤리상관.추화인자수체작위염증화면역응답적조공분자이성위다충약물적파향분자.림상상이경개시이용추화인자적념항제치료염증질병,본편지재천술추화인자급기수체재염증질병중적작용이급저사추화인자재림상상적응용.
Chemokines are small heparin-binding proteins that direct the movement of eirculating leukocytes to sites of inflammation or injury.Original studied because of their role in inflammation.Chemokines and their receptors are now known to play a crucial part in directing the movement of mononuclear cells throughout the body,engendering the adaptive immune response and contributing to the pathogenesis of a variety of diseases. Chemokine receptors are some of the most tractable drug targets in the huge battery of molecules that regulate inflammation and immunity.For this reason,clinical trials involving chemokine-receptor antagonists for the treatment of inflammatory conditions have recently began.In this review,we survey the properties of chemokines and their receptors and highlight the roles of these chemoattractants in selected clinical disorders.