国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2011年
11期
873-875
,共3页
周逢强%齐艳美%李新军%郭辉光%徐宏
週逢彊%齊豔美%李新軍%郭輝光%徐宏
주봉강%제염미%리신군%곽휘광%서굉
结肠肿瘤%细胞黏附分子%钙黏着糖蛋白类
結腸腫瘤%細胞黏附分子%鈣黏著糖蛋白類
결장종류%세포점부분자%개점착당단백류
Colonic neoplasms%Cell adhesion molecules%Cadherins
目的 探讨上皮黏附分子( EpCAM)与β-连环蛋白(β-catenin)通路蛋白在结肠癌组织中表达分布情况及其临床病理意义,研究两者之间相关性.方法 采取回顾性分析用免疫组化方法检测70例结肠癌组织和相应的癌旁组织标本中EpCAM与β-catenin表达,分析其与结肠癌临床病理特征的关系及两者之间相关性.结果 ①EpCAM和β-catenin在结肠癌组织中阳性表达分别为52例(74.3％)、55例( 78.6％)；EpCAM和β-catenin在癌旁组织中阳性表达分别为13例(15.7％)、9例(12.9％),差异有统计学意义(P＜0.05).②EpCAM与β-catenin呈现正相关表达(r =0.616,P＜O.01),③EpCAM和β-catenin表达与肿瘤分化程度、浸润深度、淋巴结转移及TNM分期有关(P＜0.05).结论 EpCAM与β-catenin通路在结肠癌存在正相关性,EpCAM和β-catenin与结肠癌关系密切,其水平表达可以作为判断结肠癌病程和愈合参考指标.
目的 探討上皮黏附分子( EpCAM)與β-連環蛋白(β-catenin)通路蛋白在結腸癌組織中錶達分佈情況及其臨床病理意義,研究兩者之間相關性.方法 採取迴顧性分析用免疫組化方法檢測70例結腸癌組織和相應的癌徬組織標本中EpCAM與β-catenin錶達,分析其與結腸癌臨床病理特徵的關繫及兩者之間相關性.結果 ①EpCAM和β-catenin在結腸癌組織中暘性錶達分彆為52例(74.3％)、55例( 78.6％)；EpCAM和β-catenin在癌徬組織中暘性錶達分彆為13例(15.7％)、9例(12.9％),差異有統計學意義(P＜0.05).②EpCAM與β-catenin呈現正相關錶達(r =0.616,P＜O.01),③EpCAM和β-catenin錶達與腫瘤分化程度、浸潤深度、淋巴結轉移及TNM分期有關(P＜0.05).結論 EpCAM與β-catenin通路在結腸癌存在正相關性,EpCAM和β-catenin與結腸癌關繫密切,其水平錶達可以作為判斷結腸癌病程和愈閤參攷指標.
목적 탐토상피점부분자( EpCAM)여β-련배단백(β-catenin)통로단백재결장암조직중표체분포정황급기림상병리의의,연구량자지간상관성.방법 채취회고성분석용면역조화방법검측70례결장암조직화상응적암방조직표본중EpCAM여β-catenin표체,분석기여결장암림상병리특정적관계급량자지간상관성.결과 ①EpCAM화β-catenin재결장암조직중양성표체분별위52례(74.3％)、55례( 78.6％)；EpCAM화β-catenin재암방조직중양성표체분별위13례(15.7％)、9례(12.9％),차이유통계학의의(P＜0.05).②EpCAM여β-catenin정현정상관표체(r =0.616,P＜O.01),③EpCAM화β-catenin표체여종류분화정도、침윤심도、림파결전이급TNM분기유관(P＜0.05).결론 EpCAM여β-catenin통로재결장암존재정상관성,EpCAM화β-catenin여결장암관계밀절,기수평표체가이작위판단결장암병정화유합삼고지표.
Objective To investigate the expressions and clinical pathological significance of EpCAM and the β-catenin pathway in colon cancer,and the correlation between EpCAM andβ-catenin.Methods Immunohistochemistry was used to detecte the expressions of EpCAM and β-catenin proteins in colon cancer tissues and corresponding adjacent tissues of 70 cases of colon cancer patients,the clinical and pathological features of colon cancer and their relationship were retrospective analyzed.Results ①EpCAM and β-catenin protein expressions in colon cancer tissue was 52 cases (74.3％) and 55 (78.6％) positive respectively; EpCAM and β-catenin proteins in cancer adjacent tissues in 13 cases( 15.7％ ) and 9 cases ( 12.9％ ) were positive,the differences were statistically significant.②the EpCAM expression is positively correlated with the β-catenin expression ( r =0.616,P ＜ 0.01 ).③The expressions of EpCAM and β-catenin correlated with the tumor differentiation,invasion depth,lymph node metastasis and TNM staging related ( P ＜ 0.05).Conclusion EpCAM and β-catenin pathways in colon cancer positively correlate,and closely correlate with colon cancer.The expression level of EpCAM and β-catenin can be used as a reference for the colon disease course and healing.
