CAJ | 학술논문

目的探讨多点刺激法运动单位数目估计( MUNE)在平山病病情判定中的意义.方法采用病例对照研究,记录35例健康人和69例平山病患者拇短展肌和小指展肌MUNE数值.结果 (1)平山病组左侧拇短展肌MUNE为145.66±126.10,左侧小指展肌MUNE为102.20±112.67,右侧拇短展肌MUNE为149.72±117.80,右侧小指展肌MUNE为64.23±69.27,较对照组显著降低(P＜0.01).(2)在临床尚未出现明显症状的肌肉也可见到MUNE明显下降,尤其在症状不显著侧(P＜0.05).结论多点刺激法MUNE检测可客观监测疾病自然过程,早期了解病情及定量评价肌肉的失神经支配情况.
목적 탐토다점자격법운동단위수목고계( MUNE)재평산병병정판정중적의의.방법 채용병례대조연구,기록35례건강인화69례평산병환자무단전기화소지전기MUNE수치.결과 (1)평산병조좌측무단전기MUNE위145.66±126.10,좌측소지전기MUNE위102.20±112.67,우측무단전기MUNE위149.72±117.80,우측소지전기MUNE위64.23±69.27,교대조조현저강저(P＜0.01).(2)재림상상미출현명현증상적기육야가견도MUNE명현하강,우기재증상불현저측(P＜0.05).결론 다점자격법MUNE검측가객관감측질병자연과정,조기료해병정급정량평개기육적실신경지배정황.
Objective To explore the significance of motor unit number estimation (MUNE) by using multiple point stimulating technique to evaluate patients with Hirayama disease (HD).Methods Multiple point stimulating technique was used to estimate the motor unit number of abductor pollicis brevis and abductor digiti minimi in 35 normal subjects [14-33 years old,mean (20.9 ±4.0) years old,33 men and 2 women]without nerve and muscle disease and 69 patients definitely diagnosed as HD [16-35 years old,mean (21.46 ±6.61 ) years old,67 men and 2 women].The differences between the two groups were examined by Fisher's exact test and t test.Results There were 42 patients with atrophy and 27 patients with normal clinical manifestation of left hand.For right hand there were 54 patients with atrophy and 15 normal.For controls,the MUNE value of left abductor pollicis brevis was 226.97 ± 30.59,while that of right side was 22g.31 ± 25.35.The MUNE value of left abductor digiti minimi was 237.43 ± 30.78,while that of right side was 240.20 ± 37.73.For HD patients,the MUNE of left abductor pollicis brevis and abductor digiti minimi was 145.66 ± 126.10 ( t =5.07,P ＜ 0.01 ) and 102.20 ± 112.67 ( t =9.31,P ＜ 0.01 )respectively,while those of right hand was 149.72 ± 117.80 ( t =5.31,P ＜ 0.01 ) and 64.23 ± 69.27 ( t =16.76,P ＜0.01 ) respectively.MUNE of left abductor digiti minimi in 17 patients that was below 200 among 27 patients with normal clinical manifestation (x2 =9.57,P =0.002).MUNE of right abductor digiti minimi in 12 patients that was below 200 among 15 patients with normal clinical manifestation ( x2 =4.64,P =0.03).Conclusions The differences of MUNE values by multiple point stimulating technique between the normal subjects and the HD patients is significant,which suggests this method is very useful to evaluate HD in the early state.