CAJ | 학술논문

目的探讨肾移植术后发生肺部感染的危险因素.方法单中心2006年10月至2010年10月进行肾移植且拥有完整临床资料的早期发生肺部感染者48例作为感染组,另选择手术时间相同、免疫抑制方案相同的48例未发生感染者作为对照组.将发生肺部感染有关的因素作为变量进行单因素及多因素Logistic回归分析.结果单因素分析显示,与肺部感染发生有关的因素分别是抗体诱导、低白蛋白水平、术后1个月泼尼松总量、家庭收入、预防应用磺胺甲(噁)唑(SMZ).消除了混杂因素后采用多因素Logistic回归分析,提示抗体诱导、低白蛋白水平、术后1个月泼尼松总量、预防应用SMZ与肺部感染相关.结论肾移植术后早期肺部感染与抗体诱导、术后1个月泼尼松总量呈正相关,与白蛋白水平、预防应用SMZ呈负相关.
목적 탐토신이식술후발생폐부감염적위험인소.방법 단중심2006년10월지2010년10월진행신이식차옹유완정림상자료적조기발생폐부감염자48례작위감염조,령선택수술시간상동、면역억제방안상동적48례미발생감염자작위대조조.장발생폐부감염유관적인소작위변량진행단인소급다인소Logistic회귀분석.결과 단인소분석현시,여폐부감염발생유관적인소분별시항체유도、저백단백수평、술후1개월발니송총량、가정수입、예방응용광알갑(오)서(SMZ).소제료혼잡인소후채용다인소Logistic회귀분석,제시항체유도、저백단백수평、술후1개월발니송총량、예방응용SMZ여폐부감염상관.결론 신이식술후조기폐부감염여항체유도、술후1개월발니송총량정정상관,여백단백수평、예방응용SMZ정부상관.
Objective To find out the risk factors of early pulmonary infections after renal transplantatioa Methods The data were collected from 96 patients receiving renal transplantation between Oct. 2006 and Oct 2010, including 48 cases of early lung infection after renal transplantation as infection group, and 48 patients receiving immunosuppressive regimen at the same period as-control group. Taking the factors of lung infecition as variables, t test or chi-square test was used in univariate analyses whereas logistic regression was used in multivariate analyses. Results Single factor analysis showed that induction therapy, albumin levels, dose of steroid in 1 month after operation,family income and prophylactic SMZ treatment were related to lung infectioa Analysis of multiple variables logistic regression revealed that induction therapy, albumin levels, dose of steroid in 1 month after operation and prophylactic SMZ treatment were related to lung infection. Conclusion The correlation analysis indicated that induction therapy and dose of steroid in 1 month after operation have positive correlations with pulmonary infection, while albumin levels and prophylactic SMZ treatment have negative correlations with pulmonary infection.