中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2012年
8期
691-694
,共4页
吴阳%李捷%张水军%赵永福%赵龙拴%马秀现%冯留顺%范正军
吳暘%李捷%張水軍%趙永福%趙龍拴%馬秀現%馮留順%範正軍
오양%리첩%장수군%조영복%조룡전%마수현%풍류순%범정군
肝肿瘤%癌,肝细胞%超声疗法%化学栓塞,治疗性
肝腫瘤%癌,肝細胞%超聲療法%化學栓塞,治療性
간종류%암,간세포%초성요법%화학전새,치료성
Liver neoplasms%Carcinoma,hepatocellular%Ultrasonic therapy%Chemoembolization,therapeutic
目的 探讨高强度聚焦超声( HIFU)联合经动脉化疗栓塞(TACE)治疗原发性肝细胞癌的疗效、预后及安全性.方法 将2009年12月至2011年6月行HIFU治疗的72例肝细胞癌患者按治疗方法分为HIFU组40例,联合组(TACE+ HIFU) 32例,同时将同期于我院接受TACE治疗的40例患者(TACE组)作为对照.分析治疗前后临床症状改善情况、甲胎蛋白、肿瘤缩小情况、术后1年生存率以及术后并发症的发生情况.结果 HIFU组、TACE组、联合组在治疗后临床症状改善方面差异无统计学意义(P＞0.05).HIFU组和TACE组的有效率分别为35.0％和37.5％,甲胎蛋白下降50％比例分别为41.4％和41.9％,差异无统计学意义(x2=0.054,P=0.816;x2 =0.002,P=0.965).联合组有效率为62.5％,甲胎蛋白下降50％比例为72.0％,大于HIFU组(x2=5.394,P=0.020;x2=5.098,P=0.024)和TACE组(x2=4.448,P=0.035;x2=5.062,P=0.024). Kaplan-Meier曲线分析结果示,联合组、HIFU组、TACE组近期生存率差异无统计学意义,远期生存率联合组要高于其他两组.结论 TACE联合HIFU治疗原发性肝细胞癌是一种有效、安全的治疗方式.
目的 探討高彊度聚焦超聲( HIFU)聯閤經動脈化療栓塞(TACE)治療原髮性肝細胞癌的療效、預後及安全性.方法 將2009年12月至2011年6月行HIFU治療的72例肝細胞癌患者按治療方法分為HIFU組40例,聯閤組(TACE+ HIFU) 32例,同時將同期于我院接受TACE治療的40例患者(TACE組)作為對照.分析治療前後臨床癥狀改善情況、甲胎蛋白、腫瘤縮小情況、術後1年生存率以及術後併髮癥的髮生情況.結果 HIFU組、TACE組、聯閤組在治療後臨床癥狀改善方麵差異無統計學意義(P＞0.05).HIFU組和TACE組的有效率分彆為35.0％和37.5％,甲胎蛋白下降50％比例分彆為41.4％和41.9％,差異無統計學意義(x2=0.054,P=0.816;x2 =0.002,P=0.965).聯閤組有效率為62.5％,甲胎蛋白下降50％比例為72.0％,大于HIFU組(x2=5.394,P=0.020;x2=5.098,P=0.024)和TACE組(x2=4.448,P=0.035;x2=5.062,P=0.024). Kaplan-Meier麯線分析結果示,聯閤組、HIFU組、TACE組近期生存率差異無統計學意義,遠期生存率聯閤組要高于其他兩組.結論 TACE聯閤HIFU治療原髮性肝細胞癌是一種有效、安全的治療方式.
목적 탐토고강도취초초성( HIFU)연합경동맥화료전새(TACE)치료원발성간세포암적료효、예후급안전성.방법 장2009년12월지2011년6월행HIFU치료적72례간세포암환자안치료방법분위HIFU조40례,연합조(TACE+ HIFU) 32례,동시장동기우아원접수TACE치료적40례환자(TACE조)작위대조.분석치료전후림상증상개선정황、갑태단백、종류축소정황、술후1년생존솔이급술후병발증적발생정황.결과 HIFU조、TACE조、연합조재치료후림상증상개선방면차이무통계학의의(P＞0.05).HIFU조화TACE조적유효솔분별위35.0％화37.5％,갑태단백하강50％비례분별위41.4％화41.9％,차이무통계학의의(x2=0.054,P=0.816;x2 =0.002,P=0.965).연합조유효솔위62.5％,갑태단백하강50％비례위72.0％,대우HIFU조(x2=5.394,P=0.020;x2=5.098,P=0.024)화TACE조(x2=4.448,P=0.035;x2=5.062,P=0.024). Kaplan-Meier곡선분석결과시,연합조、HIFU조、TACE조근기생존솔차이무통계학의의,원기생존솔연합조요고우기타량조.결론 TACE연합HIFU치료원발성간세포암시일충유효、안전적치료방식.
Objective To study on the efficacy,prognosis and security of high-intensity focused ultrasound (HIFU) combined with transcatheter arterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC).Methods Totally 72 HCC patients treated by HIFU from December 2009 to January 2011 were divided into two groups according to treatment methods:40 cases in HIFU group,32 cases in TACE + HIFU treatment group (combined group).Then set up a control group include 40 cases treated by only TACE in the same period (TACE group).The improvement of clinical symptoms,AFP,reduce rate of tumor volume,survival rate of 1 year after operation and postoperative complications in front and behind the treatment were analyzed. Results There was no significant statistical difference on the improvement of clinical symptoms in all these three groups ( P ＞ 0.05 ) after treatment for HCC.There is no significant statistical difference also on reduce rate of tumor volume and decrease rate of AFP in both HIFU group (35.0％,41.4％) and TACE group (37.5％,41.9％) (x2 =0.054,P=0.816; x2 =0.002,P=0.965 ). Both reduce rate of tumor volume (62.5％ ) and decrease rate of AFP ( 72.0％ ) in combined group were better than HIFU group ( x2 =5.394,P =0.020 ; x2 =5.098,P =0.024 ) and TACE group (37.5％,41.9％) (x2 =4.448,P=0.035; x2 =5.062,P=0.024). Kaplan-Meier survival curve showed that there was no significant statistical difference on short-term survival rate in the 3 groups.But the long-term survival rate of combined group was better than TACE group and HIFU group. Conclusion TACE combined with HIFU is a effective,safe and noninvasive treatment method to HCC.
