CAJ | 학술논문

目的探讨老年高血压患者胰岛素抵抗的特征.方法选择高血压病患者60例(老年,非老年各30例),以及与高血压组体重指数有可比性的正常血压者20例,测定其血清总胆固醇(TC),甘油三酯(TG),空腹血糖(FBG),餐后2h血糖(PBG),淋巴细胞内Ca2+的浓度,计算胰岛素敏感指数(ISI),三组逐项进行对照.结果 (1)高血压组与正常血压组对照,存在高胰岛素血症,胰岛素抵抗和多种代谢紊乱;(2)老年高血压组与非老年高血压组比较,前者TG、FBG、PBG、FINS、PINS水平和Ca2+浓度显著增高,胰岛素敏感指数显著降低.结论老年高血压有更加明显的高胰岛素血症,更严重的胰岛素抵抗和多种代谢紊乱,这可能与增龄、老化有关.
목적 탐토노년고혈압환자이도소저항적특정.방법 선택고혈압병환자60례(노년,비노년각30례),이급여고혈압조체중지수유가비성적정상혈압자20례,측정기혈청총담고순(TC),감유삼지(TG),공복혈당(FBG),찬후2h혈당(PBG),림파세포내Ca2+적농도,계산이도소민감지수(ISI),삼조축항진행대조.결과 (1)고혈압조여정상혈압조대조,존재고이도소혈증,이도소저항화다충대사문란;(2)노년고혈압조여비노년고혈압조비교,전자TG、FBG、PBG、FINS、PINS수평화Ca2+농도현저증고,이도소민감지수현저강저.결론 노년고혈압유경가명현적고이도소혈증,경엄중적이도소저항화다충대사문란,저가능여증령、노화유관.
Objective To investingate the features of insulim resistance in elderly hypertensive patients. Methods The levels of serum toatal eholesterol(TC),serum triglycedde(TG),fasfing blood glnsose(FBG),2h postprandial blood glucose(PBG),fasting insulin (FINS),2h postprandial insulim (PINS),intracellular free calcium of lymphocyte ([Ca2+i) were respecfived measured,then the insulin sensitivity index (ISI) wad calculated,and compared in 60 essential hypertensive patients (30 elderly,30 non-elderly) and 20 weight index matched normotensive control subjects. Results (1)the hypertensive patients compared with normotensive control subjects,the patients had hyperinsumlinemia,insulin resistance and multiple metabolic disorders. (2)The elderly hypertensive patients compared with the non-elderly hypertensive patients,the levels of TG,FBG,PBG,FINS,PINS and [Ca2+]i were Significantly higher but ISI was significantly lower,in the elderly hypertensive patients. Conclusion The elderly hypertensive patients had more obvious hyperonsulinemia,severe insulin resistance and multiple metaboie disorders,these maybe related to aging and degeneracy.