CAJ | 학술논문

弥漫性泛细支气管炎(diffuse panbronchiolitis,DPB)是一种小气道慢性弥漫性疾病,其确切病因不甚明确,部分学者认为DPB的发病与铜绿假单胞菌感染有关,铜绿假单胞菌多种毒力因子如杀白细胞素、外毒素A、内毒素、弹性蛋白酶和鞭毛蛋白等在引起DPB气道感染损伤过程中有着重要的作用,同时铜绿假单胞菌密度感应信号系统参与调节这些毒力因子的基因表达过程.
미만성범세지기관염(diffuse panbronchiolitis,DPB)시일충소기도만성미만성질병,기학절병인불심명학,부분학자인위DPB적발병여동록가단포균감염유관,동록가단포균다충독력인자여살백세포소、외독소A、내독소、탄성단백매화편모단백등재인기DPB기도감염손상과정중유착중요적작용,동시동록가단포균밀도감응신호계통삼여조절저사독력인자적기인표체과정.
Diffuse panbronchiolitis(DPB) is a chronic progressive disease of the lower respiratorytract, but the detailed mechanisms of DPB has not been well defined. Some of researchers thought it would beconnected with Pseudomonas aeruginosa infection. A number of the bacterial virulence factors, includingleukocidin,exotoxin A, endotoxin, elastase and flagellin, play an important role in the pulmonary damage.Quorum sensing system can regulate gene expression of those virulence factors.